1H-Pyrrole-2-carboxylicacid,1-amino-,ethylester(9CI)

Base Information

• Chemical Name: 1H-Pyrrole-2-carboxylicacid,1-amino-,ethylester(9CI)
• CAS No.: 628733-99-3
• Molecular Formula: C7H10N2O2
• Molecular Weight: 154.17
• Hs Code.: 2933990090
• Mol file: 628733-99-3.mol

Synonyms:1H-Pyrrole-2-carboxylicacid,1-amino-,ethylester(9CI);Ethyl 1-aMino-1H-pyrrole-2-carboxylate

Chemical Property of 1H-Pyrrole-2-carboxylicacid,1-amino-,ethylester(9CI)

Chemical Property:

• Boiling Point: 284.0±32.0 °C(Predicted)
• PKA: -3.55±0.70(Predicted)
• PSA: 57.25000
• Density: 1.21±0.1 g/cm3(Predicted)
• LogP: 0.95980
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

Ethyl1-amino-1H-pyrrole-2-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrole-2-carboxylicacid,1-amino-,ethylester(9CI)

There total 2 articles about 1H-Pyrrole-2-carboxylicacid,1-amino-,ethylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl 1H-pyrrole-2-carboxylate (2199-43-1) → ethyl 1-amino-1H-pyrrole-2-carboxylate (628733-99-3)

Guidance literature:

ethyl 1H-pyrrole-2-carboxylate; With sodium hydride; In DMF (N,N-dimethyl-formamide); at 0 ℃; for 1h;

With O-(2,4-dinitrophenyl)hydroxylamine; In DMF (N,N-dimethyl-formamide); at 0 ℃; for 2.5h;

Reference yield: 90.0%

aqueous Na2S2O3 + 2,4-dinitrophenolamine + ethyl 1H-pyrrole-2-carboxylate (2199-43-1) → ethyl 1-amino-1H-pyrrole-2-carboxylate (628733-99-3)

Guidance literature:

In N,N-dimethyl-formamide;

Reference yield: 50.0%

ethyl 1-amino-1H-pyrrole-2-carboxylate (628733-99-3) + ethyl (3-methoxybenzoyl)acetate (27834-99-7) → ethyl 2-(3-methoxyphenyl)-4-oxo-1,4-dihydropyrrolo[1,2-b]pyridazine-7-carboxylate

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In 1,1,2,2-tetrachloroethane; at 140 ℃;

DOI:10.1002/ejoc.201500422

upstream raw materials:

ethyl 1H-pyrrole-2-carboxylate

Downstream raw materials:

1-(3-benzoyl-thioureido)-1H-pyrrole-2-carboxylic acid ethyl ester

4-(1-(2,4-dichlorophenyl)cyclopropylamino)pyrrolo[1,2-b]pyridazine-3-carbonitrile

4-(1-(2,4-dichlorophenyl)cyclopropylamino)pyrrolo[1,2-b]pyridazine-3-carboxamide

4-(2-(2-methoxyphenyl)-2-morpholinoethylamino)pyrrolo[1,2-b]pyridazine-3-carbonitrile

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