1-(Thiophen-3-yl)ethanamine

Base Information

• Chemical Name: 1-(Thiophen-3-yl)ethanamine
• CAS No.: 118488-08-7
• Molecular Formula: C6H9NS
• Molecular Weight: 127.21
• Hs Code.: 2934999090
• European Community (EC) Number: 692-912-6
• DSSTox Substance ID: DTXSID20557980
• Mol file: 118488-08-7.mol

Synonyms:1-(Thiophen-3-yl)ethanamine;118488-08-7;1-thiophen-3-ylethanamine;1-(3-thienyl)ethanamine;1-(thiophen-3-yl)ethan-1-amine;[1-(3-Thienyl)ethyl]amine;[1-(Thien-3-yl)ethyl]amine;SCHEMBL142218;DTXSID20557980;KXCGQPCMPZULFH-UHFFFAOYSA-N;CS-D0194;(+/-)-1-thiophen-3-yl-ethylamine;MFCD08452688;1-(3-Thienyl)ethanamine, AldrichCPR;AKOS005215166;LS-06642;EN300-61890;Z513796194

Chemical Property of 1-(Thiophen-3-yl)ethanamine

Chemical Property:

• Vapor Pressure: 0.328mmHg at 25°C
• Boiling Point: 200.242°C at 760 mmHg
• PKA: 10.04±0.29(Predicted)
• Flash Point: 74.904°C
• PSA: 54.26000
• Density: 1.095g/cm³
• LogP: 2.46810
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 127.04557046
• Heavy Atom Count: 8
• Complexity: 74.9

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-(Thiophen-3-yl)ethanamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CSC=C1)N

Technology Process of 1-(Thiophen-3-yl)ethanamine

There total 5 articles about 1-(Thiophen-3-yl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(3-thienyl)ethylazide (118488-07-6) → 1-(thiophen-3-yl)ethylamine (118488-08-7)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 1h; Heating;

Reference yield: 90.0%

→ 1-(thiophen-3-yl)ethylamine (118488-08-7)

Guidance literature:

Reference yield: 84.0%

1-(thiophen-3-yl)-ethanone (1468-83-3) → 1-(thiophen-3-yl)ethylamine (118488-08-7)

Guidance literature:

With formic acid; ammonium formate; C₂₁H₂₄ClIrN₂O; In methanol; for 8h; Inert atmosphere; Schlenk technique; Reflux;

DOI:10.1039/d1ob01710a

upstream raw materials:

1-(3-thienyl)ethylazide

1-(thiophen-3-yl)-ethanone

3-(1-chloroethyl)thiophene

1-(thiophen-3-yl)ethan-1-ol

Refernces

• 1、 Wei, Binqing,Gunzner-Toste, Janet,Yao, Hui,Wang, Tao,Wang, Jing,Xu, Zijin,Chen, Jinhua,Wai, John,Nonomiya, Jim,Tsai, Siao Ping,Chuh, Josefa,Kozak, Katherine R.,Liu, Yichin,Yu, Shang-Fan,Lau, Jeff,Li, Guangmin,Phillips, Gail D.,Leipold, Doug,Kamath, Amrita,Su, Dian,Xu, Keyang,Eigenbrot, Charles,Steinbacher, Stefan,Ohri, Rachana,Raab, Helga,Staben, Leanna R.,Zhao, Guiling,Flygare, John A.,Pillow, Thomas H.,Verma, Vishal,Masterson, Luke A.,Howard, Philip W.,Safina, Brian. "Discovery of Peptidomimetic Antibody-Drug Conjugate Linkers with Enhanced Protease Specificity". supporting information. p. 989 - 1000. Retrieved 2018/01/01.
• 2、 -. "PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF". Page/Page column 80; 81. . Retrieved 2015/07/07.