4-METHOXY-2,3,6-TRIMETHYLBENZYL ALCOHOL

Base Information

• Chemical Name: 4-METHOXY-2,3,6-TRIMETHYLBENZYL ALCOHOL
• CAS No.: 54344-93-3
• Molecular Formula: C11H16O2
• Molecular Weight: 180.24354
• Hs Code.: 2909499000
• Mol file: 54344-93-3.mol

Synonyms:4-METHOXY-2,3,6-TRIMETHYLBENZYL ALCOHOL;4-Methoxy-2,3,6-triMethyl-benzeneMethanol;(4-methoxy-2,3,6-trimethylphenyl)methanol

Chemical Property of 4-METHOXY-2,3,6-TRIMETHYLBENZYL ALCOHOL

Chemical Property:

• PSA: 29.46000
• LogP: 2.11270
• Solubility.: Chloroform, Dichloromethane, Tetrahydrofuran

Purity/Quality:

97% ^*data from raw suppliers

4-Methoxy-2,3,6-trimethylbenzylAlcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Methoxy-2,3,6-trimethylbenzyl Alcohol (cas# 54344-93-3) is a compound useful in organic synthesis.

Technology Process of 4-METHOXY-2,3,6-TRIMETHYLBENZYL ALCOHOL

There total 5 articles about 4-METHOXY-2,3,6-TRIMETHYLBENZYL ALCOHOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,3,6-trimethyl-4-methoxy-benzaldehyde (54344-92-2) → (4-methoxy-2,3,6-trimethylphenyl)methanol (54344-93-3)

Guidance literature:

With sodium tetrahydroborate; ethanol; at 80 ℃; for 3h;

DOI:10.1002/chem.201403024

Reference yield:

2,3,5-trimethylphenol (697-82-5) → (4-methoxy-2,3,6-trimethylphenyl)methanol (54344-93-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 12 h / 25 °C

2.1: trichlorophosphate / 0.25 h / 10 - 20 °C

2.2: 6 h / 10 - 110 °C

3.1: sodium tetrahydroborate; ethanol / 3 h / 80 °C

With sodium tetrahydroborate; ethanol; sodium hydride; trichlorophosphate; In tetrahydrofuran; mineral oil;

DOI:10.1002/chem.201403024

Reference yield:

2,3,5-trimethylanisole (20469-61-8) → (4-methoxy-2,3,6-trimethylphenyl)methanol (54344-93-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) POCl₃ / 1.) 0 deg C, 2 h, 2.) 70 deg, 24 h

2: 93 percent / LiAlH₄

With lithium aluminium tetrahydride; trichlorophosphate;

DOI:10.1002/jlac.198419841014

upstream raw materials:

2,3,6-trimethyl-4-methoxy-benzaldehyde

2,3,5-trimethylanisole

2,3,5-trimethylphenol

Downstream raw materials:

2,3,6,2’,3’,6’-hexamethyl-4,4’-dimethoxy-trans-stilbene

2,3,6,2’,3’,6’-hexamethyl-4,4’-dihydroxy-trans-stilbene

ethyl 2(E),4(E),6(E),8(Z)-3,7-dimethyl-9-fluoro-9-(4-methoxy-2,3,6-trimethylphenyl)-nonatetraenoate

ethyl 2(E),4(E),6(E),8(E)-3,7-dimethyl-9-fluoro-9-(4-methoxy-2,3,6-trimethylphenyl)-nonatetraenoate