N-(4-ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide

Base Information

Chemical Name:N-(4-ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide
CAS No.:1474110-21-8
Molecular Formula:C₂₅H₃₅NO₅S
Molecular Weight:461.623
Hs Code.:
Mol file:1474110-21-8.mol

Synonyms:N-(4-ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide;ROR gama modulator 1;GSK2981278

Suppliers and Price of N-(4-ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
GSK2981278 >98%
250 mg
$ 1000.00

DC Chemicals
GSK2981278 >98%
1 g
$ 1900.00

Crysdot
RORgamamodulator1 98+%
10mg
$ 347.00

Crysdot
RORgamamodulator1 98+%
5mg
$ 243.00

Crysdot
RORgamamodulator1 98+%
100mg
$ 1459.00

Crysdot
RORgamamodulator1 98+%
50mg
$ 1042.00

ChemScene
GSK2981278 99.70%
100mg
$ 790.00

ChemScene
GSK2981278 99.70%
50mg
$ 490.00

ChemScene
GSK2981278 99.70%
10mg
$ 160.00

ChemScene
GSK2981278 99.70%
5mg
$ 160.00

Total 16 raw suppliers

Chemical Property of N-(4-ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide

Chemical Property:

Boiling Point:622.6±65.0 °C(Predicted)
PKA:14.10±0.10(Predicted)
PSA：84.45000
Density:1.180±0.06 g/cm3(Predicted)
LogP:5.47880
Solubility.:≤15mg/ml in ethanol;5mg/ml in DMSO;30mg/ml in dimethyl formamide

Purity/Quality:

99%, ^*data from raw suppliers

GSK2981278 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(4-ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide

There total 23 articles about N-(4-ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: isobutyl 5-(N-(4-ethylphenyl)-N-isobutylsulfamoyl)-2-((tetrahydro-2H-pyran-4-yl)methoxy)benzoate

: 1474110-21-8
N-(4-ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; at -10 - 25 ℃; for 4h; Large scale;
DOI:10.1021/acs.oprd.9b00147

Reference yield: 38.0%

: methyl 5-(N-(4-ethylphenyl)-N-isobutylsulfamoyl)-2-((tetrahydro-2H-pyran-4-yl)methoxy)benzoate

: 1474110-21-8
N-(4-ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide

Guidance literature:: With lithium triethylborohydride; In tetrahydrofuran; at 25 ℃; for 1h;
DOI:10.1021/acs.jmedchem.1c01436

Reference yield:

: 589-16-2
4-aminoethylbenzene

: 1474110-21-8
N-(4-ethylphenyl)-3-(hydroxymethyl)-N-isobutyl-4-((tetrahydro-2H-pyran-4-yl)methoxy)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium iodide; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] / water / 1.5 h / 150 °C / Microwave irradiation; Sealed tube

2: pyridine / 1.5 h / 20 °C

3: cyanomethylenetributyl-phosphorane / toluene / 20 °C

4: lithium triethylborohydride; tetrahydrofuran / 1 h / Inert atmosphere

With tetrahydrofuran; pyridine; bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; lithium triethylborohydride; cyanomethylenetributyl-phosphorane; potassium iodide; In water; toluene;