1-Pyrrolidinecarboxylic acid, 2-(chlorocarbonyl)-5-oxo-, methyl ester, (S)- (9CI)

Base Information

• Chemical Name: 1-Pyrrolidinecarboxylic acid, 2-(chlorocarbonyl)-5-oxo-, methyl ester, (S)- (9CI)
• CAS No.: 172988-55-5
• Molecular Formula: C₇H₈ClNO₄
• Molecular Weight: 205.598
• Mol file: 172988-55-5.mol

Synonyms:1-Pyrrolidinecarboxylic acid, 2-(chlorocarbonyl)-5-oxo-, methyl ester, (S)- (9CI)

Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-(chlorocarbonyl)-5-oxo-, methyl ester, (S)- (9CI)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-Pyrrolidinecarboxylic acid, 2-(chlorocarbonyl)-5-oxo-, methyl ester, (S)- (9CI)

There total 2 articles about 1-Pyrrolidinecarboxylic acid, 2-(chlorocarbonyl)-5-oxo-, methyl ester, (S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trimethylsilyl N-methoxycarbonylpyroglutamate → N-methoxycarbonylpyroglutamoyl chloride (172988-55-5)

Guidance literature:

With thionyl chloride; In dichloromethane; Heating;

DOI:10.1002/jhet.5570320532

Reference yield:

oxoproline TMS (30274-77-2) → N-methoxycarbonylpyroglutamoyl chloride (172988-55-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / 4 h / Heating

2: SOCl₂ / CH₂Cl₂ / Heating

With thionyl chloride; In dichloromethane;

DOI:10.1002/jhet.5570320532

Reference yield:

p-toluidine (106-49-0,12221-03-3) + N-methoxycarbonylpyroglutamoyl chloride (172988-55-5) → 1-methoxycarbonyl-N-(4-methylphenyl)pyroglutamide

Guidance literature:

In dichloromethane; for 1h; Heating;

DOI:10.1002/jhet.5570320532

upstream raw materials:

oxoproline TMS

Refernces