(2R,3R)-3-AMINO-3-(4-FLUORO-PHENYL)-2-HYDROXY-PROPIONIC ACID

Base Information

• Chemical Name: (2R,3R)-3-AMINO-3-(4-FLUORO-PHENYL)-2-HYDROXY-PROPIONIC ACID
• CAS No.: 55652-55-6
• Molecular Formula: C₉H₁₀FNO₃
• Molecular Weight: 199.182
• Mol file: 55652-55-6.mol

Synonyms:(2R,3R)-3-AMINO-3-(4-FLUORO-PHENYL)-2-HYDROXY-PROPIONIC ACID

Chemical Property of (2R,3R)-3-AMINO-3-(4-FLUORO-PHENYL)-2-HYDROXY-PROPIONIC ACID

Chemical Property:

• PSA: 83.55000
• LogP: 0.97130
• Storage Temp.: 2-8°C

Purity/Quality:

HPLC>98% ^*data from raw suppliers

(2R,3R)-3-Amino-3-(4-fluorophenyl)-2-hydroxypropanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R,3R)-3-AMINO-3-(4-FLUORO-PHENYL)-2-HYDROXY-PROPIONIC ACID

There total 4 articles about (2R,3R)-3-AMINO-3-(4-FLUORO-PHENYL)-2-HYDROXY-PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C9H7FO3 → β-(p-Fluorphenyl)isoserin (55652-55-6,56972-37-3,56978-13-3) + 3-(4-fluorophenyl)serine (322-03-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / Cooling with ice

2: (S)-2-amino-5-phenylpent-4-enoic acid / aq. phosphate buffer / pH 8 / Enzymatic reaction

With (S)-2-amino-5-phenylpent-4-enoic acid; potassium hydroxide; In aq. phosphate buffer; ethanol;

DOI:10.1021/acscatal.9b01557

Reference yield:

potassium 3-(4-fluorophenyl)oxirane-2-carboxylate → β-(p-Fluorphenyl)isoserin (55652-55-6,56972-37-3,56978-13-3) + 3-(4-fluorophenyl)serine (322-03-2)

Guidance literature:

With (S)-2-amino-5-phenylpent-4-enoic acid; In aq. phosphate buffer; pH=8; Enzymatic reaction;

DOI:10.1021/acscatal.9b01557

Reference yield:

(E)-4-fluorocinnamic acid (459-32-5) → β-(p-Fluorphenyl)isoserin (55652-55-6,56972-37-3,56978-13-3) + 3-(4-fluorophenyl)serine (322-03-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate; oxone; edetate disodium / acetone; water / 7 h / 25 °C / pH 7.5

1.2: pH 2

2.1: potassium hydroxide / ethanol / Cooling with ice

3.1: (S)-2-amino-5-phenylpent-4-enoic acid / aq. phosphate buffer / pH 8 / Enzymatic reaction

With oxone; edetate disodium; sodium hydrogencarbonate; (S)-2-amino-5-phenylpent-4-enoic acid; potassium hydroxide; In aq. phosphate buffer; ethanol; water; acetone;

DOI:10.1021/acscatal.9b01557

upstream raw materials:

(E)-4-fluorocinnamic acid

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