(R)-tert-Butyl 1-oxo-1-(2-(pyridin-2-yl)hydrazinyl)propan-2-ylcarbamate

Base Information

• Chemical Name: (R)-tert-Butyl 1-oxo-1-(2-(pyridin-2-yl)hydrazinyl)propan-2-ylcarbamate
• CAS No.: 915375-27-8
• Molecular Formula: C₁₃H₂₀N₄O₃
• Molecular Weight: 280.327
• Hs Code.: 2933990090
• Mol file: 915375-27-8.mol

Synonyms:(R)-tert-Butyl 1-oxo-1-(2-(pyridin-2-yl)hydrazinyl)propan-2-ylcarbamate

Chemical Property of (R)-tert-Butyl 1-oxo-1-(2-(pyridin-2-yl)hydrazinyl)propan-2-ylcarbamate

Chemical Property:

• Boiling Point: 407.2±41.0 °C(Predicted)
• PKA: 11.31±0.46(Predicted)
• PSA: 92.35000
• Density: 1.186±0.06 g/cm3(Predicted)
• LogP: 2.29270
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-tert-Butyl(1-oxo-1-(2-(pyridin-2-yl)hydrazinyl)propan-2-yl)carbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-tert-Butyl 1-oxo-1-(2-(pyridin-2-yl)hydrazinyl)propan-2-ylcarbamate

There total 1 articles about (R)-tert-Butyl 1-oxo-1-(2-(pyridin-2-yl)hydrazinyl)propan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

pyrid-2-ylhydrazine (4930-98-7) + Boc-(R)-Ala (3744-87-4,7764-95-6,15761-38-3) → [1-(N'-pyridin-2-yl-hydrazinocarbonyl)-ethyl]-carbamic acid tert-butyl ester (915375-27-8)

Guidance literature:

With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In dichloromethane; for 2h;

DOI:10.1016/j.tetlet.2006.08.075

Reference yield: 70.0%

[1-(N'-pyridin-2-yl-hydrazinocarbonyl)-ethyl]-carbamic acid tert-butyl ester (915375-27-8) → (1-[1,2,4]triazolo[4,3-a]pyridin-3-yl-ethyl)-carbamic acid tert-butyl ester (915375-35-8)

Guidance literature:

With Lawessons reagent; In 1,2-dimethoxyethane; at 80 ℃; for 2h;

DOI:10.1016/j.tetlet.2006.08.075

Reference yield:

[1-(N'-pyridin-2-yl-hydrazinocarbonyl)-ethyl]-carbamic acid tert-butyl ester (915375-27-8) → 1-[1,2,4]triazolo[4,3-a]pyridin-3-yl-ethylamine (1217810-82-6,900641-16-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / Lawesson's reagent / 1,2-dimethoxy-ethane / 2 h / 80 °C

2: HCl / methanol

With Lawessons reagent; hydrogenchloride; In methanol; 1,2-dimethoxyethane;

DOI:10.1016/j.tetlet.2006.08.075

upstream raw materials:

pyrid-2-ylhydrazine

Boc-(R)-Ala

Downstream raw materials:

(1-[1,2,4]triazolo[4,3-a]pyridin-3-yl-ethyl)-carbamic acid tert-butyl ester

1-[1,2,4]triazolo[4,3-a]pyridin-3-yl-ethylamine

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