7-Bromo-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester

Base Information

Chemical Name:7-Bromo-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester
CAS No.:1189107-52-5
Molecular Formula:C13H12BrNO3
Molecular Weight:310.14328
Hs Code.:
Mol file:1189107-52-5.mol

Synonyms:7-Bromo-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester

Suppliers and Price of 7-Bromo-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
3-Quinolinecarboxylicacid,7-bromo4-hydroxy-8-methyl-,ethylester
100mg
$ 131.60

Acrotein
Ethyl7-bromo-4-hydroxy-8-methylquinoline-3-carboxylate 97%
0.1g
$ 158.33

Total 4 raw suppliers

Chemical Property of 7-Bromo-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester

Chemical Property:

Boiling Point:400.5±40.0 °C(Predicted)
PKA:2.33±0.50(Predicted)
PSA：59.16000
Density:1.534±0.06 g/cm3(Predicted)
LogP:2.77570

Purity/Quality:

98%Min ^*data from raw suppliers

3-Quinolinecarboxylicacid,7-bromo4-hydroxy-8-methyl-,ethylester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 7-Bromo-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester

There total 2 articles about 7-Bromo-4-hydroxy-8-methylquinoline-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1445790-54-4
diethyl 2-(((3-bromo-2-methylphenyl)amino)methylene)-malonate

: 1189107-52-5
ethyl 7-bromo-4-hydroxy-8-methylquinoline-3-carboxylate

Guidance literature:: In diphenylether; at 250 ℃; for 16h;

Reference yield:

: 55289-36-6
3-bromo-2-methylaniline

: 87-13-8
diethyl 2-ethoxymethylenemalonate

: 1189107-52-5
ethyl 7-bromo-4-hydroxy-8-methylquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.5 h / 100 °C

2: diphenylether / 16 h / 250 °C

In diphenylether;

Reference yield:

: 1189107-52-5
ethyl 7-bromo-4-hydroxy-8-methylquinoline-3-carboxylate

: 1445787-33-6
3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)-8-methylquinolin-4-yl)amino)-5-cyclopentylbenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide; water / tetrahydrofuran; methanol / 2 h / 45 °C

2.1: trichlorophosphate / 3 h / 110 °C

2.2: Cooling with ice

3.1: acetic acid / 65 h / 20 °C

4.1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.5 h / 100 °C

5.1: potassium hydroxide; water / tetrahydrofuran; methanol / 16 h / 45 °C

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; caesium carbonate; acetic acid; potassium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; water;