Methyl 2-(5-amino-2-pyridinyl)-2-methylpropanoate

Base Information

Chemical Name:Methyl 2-(5-amino-2-pyridinyl)-2-methylpropanoate
CAS No.:292600-24-9
Molecular Formula:C10H14N2O2
Molecular Weight:194.23
Hs Code.:
Mol file:292600-24-9.mol

Synonyms:Methyl 2-(5-amino-2-pyridinyl)-2-methylpropanoate;methyl 2-(5-aminopyridin-2-yl)-2-methylpropanoate

Suppliers and Price of Methyl 2-(5-amino-2-pyridinyl)-2-methylpropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of Methyl 2-(5-amino-2-pyridinyl)-2-methylpropanoate

Chemical Property:

Boiling Point:324.6±32.0 °C(Predicted)
PKA:5.31±0.22(Predicted)
PSA：65.21000
Density:1.131±0.06 g/cm3(Predicted)
LogP:1.69560

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Methyl 2-(5-amino-2-pyridinyl)-2-methylpropanoate

There total 1 articles about Methyl 2-(5-amino-2-pyridinyl)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 292600-23-8
methyl 2-methyl-2-(5-nitropyridin-2-yl)propionate

: 292600-24-9
methyl 2-(5-aminopyridin-2-yl)-2-methylpropionate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 0.75h; under 2585.74 Torr;
DOI:10.1016/S0040-4039(01)01322-3

Reference yield:

: 292600-24-9
methyl 2-(5-aminopyridin-2-yl)-2-methylpropionate

: 5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-3-[2-(3,5-dinitro-benzenesulfonylamino)-1-methyl-ethyl]-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 13 steps

1: NEt₃ / tetrahydrofuran; diethyl ether / 0.75 h / 0 - 20 °C

2: NaOH / methanol / 50 °C

3: PyBOP; NEt₃ / CH₂Cl₂ / 15 h / 20 °C

4: 69 percent / t-BuLi; I₂ / tetrahydrofuran / -78 - -10 °C

5: 78 percent / H₂SO₄ / H₂O / 3.5 h / 95 °C

6: 62 percent / LiCl; Na₂CO₃ / Pd(dppf)Cl₂*CH₂Cl₂ / dimethylformamide / 15 h / 100 °C

7: 98 percent / IPy₂BF₄; TfOH / CH₂Cl₂ / 1.5 h / 20 °C

8: 100 percent / Na₂CO₃ / Pd(dppf)Cl₂*CH₂Cl₂ / ethanol; toluene / 15 h / 90 °C

9: 89 percent / DMAP; K₂CO₃ / CH₂Cl₂ / 1 h / 20 °C

10: 84 percent / H₂ / Pd(OH)2/C / ethanol; acetic acid / 48 h / 20 °C / 2585.74 Torr

11: Zn(N₃)2*2Py; PPh₃; imidazole / DEAD / CH₂Cl₂ / 15 h / 20 °C

12: H₂ / Pd(OH)2/C / ethanol / 1.5 h / 20 °C / 2585.74 Torr

13: 90 percent / NaHCO₃ / CH₂Cl₂; H₂O / 0.5 h / 20 °C

With 1H-imidazole; dmap; zinc azide * 2 pyridine; Barluenga reagent; trifluorormethanesulfonic acid; sulfuric acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; iodine; tert.-butyl lithium; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; triethylamine; triphenylphosphine; lithium chloride; palladium dihydroxide; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; diethylazodicarboxylate; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; toluene; 8: Suzuki-Miayura cross-coupling;
DOI:10.1016/S0040-4039(01)01322-3

Reference yield:

: 292600-24-9
methyl 2-(5-aminopyridin-2-yl)-2-methylpropionate

: 292600-31-8
(S)-1-(2-Azabicyclo[2.2.2]oct-2-yl)-2-[3-(2-benzyloxy-1-methylethyl)-2-iodo-1H-pyrrolo[2,3-c]pyridin-5-yl]-2-methyl propan-1-one

Guidance literature:: Multi-step reaction with 7 steps

1: NEt₃ / tetrahydrofuran; diethyl ether / 0.75 h / 0 - 20 °C

2: NaOH / methanol / 50 °C

3: PyBOP; NEt₃ / CH₂Cl₂ / 15 h / 20 °C

4: 69 percent / t-BuLi; I₂ / tetrahydrofuran / -78 - -10 °C

5: 78 percent / H₂SO₄ / H₂O / 3.5 h / 95 °C

6: 62 percent / LiCl; Na₂CO₃ / Pd(dppf)Cl₂*CH₂Cl₂ / dimethylformamide / 15 h / 100 °C

7: 98 percent / IPy₂BF₄; TfOH / CH₂Cl₂ / 1.5 h / 20 °C

With Barluenga reagent; trifluorormethanesulfonic acid; sulfuric acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; iodine; tert.-butyl lithium; sodium carbonate; triethylamine; lithium chloride; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)01322-3