tert-butyl 8-benzyl-3,8-diaza-bicyclo[3.2.1]octane-3-carboxylate

Base Information

• Chemical Name: tert-butyl 8-benzyl-3,8-diaza-bicyclo[3.2.1]octane-3-carboxylate
• CAS No.: 201162-52-9
• Molecular Formula: C18H26N2O2
• Molecular Weight: 302.417
• Hs Code.: 2933990090
• Mol file: 201162-52-9.mol

Synonyms:tert-butyl 8-benzyl-3,8-diaza-bicyclo[3.2.1]octane-3-carboxylate;(1R,5S)-tert-butyl 8-benzyl-3,8-diazabicyclo[3.2.1]octane-3-carboxylate

Chemical Property of tert-butyl 8-benzyl-3,8-diaza-bicyclo[3.2.1]octane-3-carboxylate

Chemical Property:

• Boiling Point: 393.4±35.0 °C(Predicted)
• PKA: 8.93±0.20(Predicted)
• PSA: 32.78000
• Density: 1.117±0.06 g/cm3(Predicted)
• LogP: 3.14610

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl8-benzyl-3,8-diazabicyclo[3.2.1]octane-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl 8-benzyl-3,8-diaza-bicyclo[3.2.1]octane-3-carboxylate

There total 4 articles about tert-butyl 8-benzyl-3,8-diaza-bicyclo[3.2.1]octane-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

di-tert-butyl dicarbonate (24424-99-5) + 8-benzyl-3,8-diazabicyclo[3.2.1]octane (93428-56-9) → 8-Benzyl-3,8-diaza-bicyclo[3.2.1]octane-3-carboxylic Acid tert-butyl Ester (201162-52-9)

Guidance literature:

In dichloromethane; Ambient temperature;

DOI:10.1021/jm970427p

Reference yield:

benzyl chloride (100-44-7) → 8-Benzyl-3,8-diaza-bicyclo[3.2.1]octane-3-carboxylic Acid tert-butyl Ester (201162-52-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / K₂CO₃ / acetone / Heating

2: 95 percent / aq. HCl / 3 h / Heating

3: 97 percent / CH₂Cl₂ / Ambient temperature

With hydrogenchloride; potassium carbonate; In dichloromethane; acetone;

DOI:10.1021/jm970427p

Reference yield:

8-benzyl-3-propionyl-3,8-diaza-bicyclo[3.2.1]octane (98068-06-5) → 8-Benzyl-3,8-diaza-bicyclo[3.2.1]octane-3-carboxylic Acid tert-butyl Ester (201162-52-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / aq. HCl / 3 h / Heating

2: 97 percent / CH₂Cl₂ / Ambient temperature

With hydrogenchloride; In dichloromethane;

DOI:10.1021/jm970427p

upstream raw materials:

di-tert-butyl dicarbonate

8-benzyl-3,8-diazabicyclo[3.2.1]octane

benzyl chloride

8-benzyl-3-propionyl-3,8-diaza-bicyclo[3.2.1]octane

Downstream raw materials:

tert-butyl (1R,5S)-3,8-diazabicyclo[3.2.1]octane-3-carboxylate

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