4-Chloro-2,6-pyridinedicarbonitrile

Base Information

• Chemical Name: 4-Chloro-2,6-pyridinedicarbonitrile
• CAS No.: 55306-66-6
• Molecular Formula: C₇H₂ClN₃
• Molecular Weight: 163.566
• Hs Code.: 2933399990
• Mol file: 55306-66-6.mol

Synonyms:4-Chloro-2,6-pyridinedicarbonitrile;4-Chloropyridine-2,6-dicarbonitrile

Chemical Property of 4-Chloro-2,6-pyridinedicarbonitrile

Chemical Property:

• Boiling Point: 271.0±35.0 °C(Predicted)
• PKA: -8.67±0.10(Predicted)
• PSA: 60.47000
• Density: 1.43±0.1 g/cm3(Predicted)
• LogP: 1.47836
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Chloropyridine-2,6-dicarbonitrile 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Chloro-2,6-pyridinedicarbonitrile

There total 2 articles about 4-Chloro-2,6-pyridinedicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-chloro-pyridine-2,6-dicarboxamide (60494-50-0) → 4-chloropyridine-2,6-dicarbonitrile (55306-66-6)

Guidance literature:

With triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; at 0 ℃; for 8h;

DOI:10.1002/anie.201200071

Reference yield:

dimethyl 4-chloro-2,6-pyridinedicarboxylate (5371-70-0) → 4-chloropyridine-2,6-dicarbonitrile (55306-66-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium hydroxide / methanol / 3 h / 50 °C

2: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 8 h / 0 °C

With ammonium hydroxide; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; methanol;

DOI:10.1002/anie.201200071

Reference yield: 60.0%

4-chloropyridine-2,6-dicarbonitrile (55306-66-6) + 4-(diphenylamino)phenyl boronic acid (201802-67-7) → 4-(4-diphenylaminophenyl)pyridine-2,6-dicarbonitrile

Guidance literature:

With palladium diacetate; potassium carbonate; triphenylphosphine; In 1,4-dioxane; for 24h; Reflux; Inert atmosphere;

DOI:10.1039/c5ra11984g

upstream raw materials:

4-chloro-pyridine-2,6-dicarboxamide

dimethyl 4-chloro-2,6-pyridinedicarboxylate

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