1-BENZYL-4-HYDROXY-4-METHYLPYRROLIDIN-2-ONE

Base Information

• Chemical Name: 1-BENZYL-4-HYDROXY-4-METHYLPYRROLIDIN-2-ONE
• CAS No.: 71392-17-1
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.257
• Mol file: 71392-17-1.mol

Synonyms:1-BENZYL-4-HYDROXY-4-METHYLPYRROLIDIN-2-ONE;2-Pyrrolidinone, 4-hydroxy-4-methyl-1-(phenylmethyl)-

Chemical Property of 1-BENZYL-4-HYDROXY-4-METHYLPYRROLIDIN-2-ONE

Chemical Property:

Purity/Quality:

95+% ^*data from raw suppliers

1-Benzyl-4-hydroxy-4-methylpyrrolidin-2-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-BENZYL-4-HYDROXY-4-METHYLPYRROLIDIN-2-ONE

There total 5 articles about 1-BENZYL-4-HYDROXY-4-METHYLPYRROLIDIN-2-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C21H27O3N (945257-34-1) → 1-benzyl-4-hydroxy-4-methyl-pyrrolidin-2-one (71392-17-1)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂; conc. HCl / Pd/C / ethanol / 1 h / 20 °C / atmospheric pressure

2: 1 h / Heating

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1080/00397910701319023

Reference yield:

1-(dibenzylamino)-2-propanone (68543-42-0) → 1-benzyl-4-hydroxy-4-methyl-pyrrolidin-2-one (71392-17-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium diisopropylamide / tetrahydrofuran; hexane / -78 °C

1.2: tetrahydrofuran; hexane / -78 - 20 °C

2.1: H₂; conc. HCl / Pd/C / ethanol / 1 h / 20 °C / atmospheric pressure

3.1: 1 h / Heating

With hydrogenchloride; hydrogen; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane;

DOI:10.1080/00397910701319023

Reference yield:

dibenzylamine (103-49-1) → 1-benzyl-4-hydroxy-4-methyl-pyrrolidin-2-one (71392-17-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium diisopropylamide / tetrahydrofuran; hexane / -78 °C

1.2: tetrahydrofuran; hexane / -78 - 20 °C

2.1: H₂; conc. HCl / Pd/C / ethanol / 1 h / 20 °C / atmospheric pressure

3.1: 1 h / Heating

With hydrogenchloride; hydrogen; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane;

DOI:10.1080/00397910701319023

upstream raw materials:

C₂₁H₂₇O₃N

1-(dibenzylamino)-2-propanone

dibenzylamine

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