N-Phenyl-2-pyrrolidinecarboxamide hydrochloride

Base Information

• Chemical Name: N-Phenyl-2-pyrrolidinecarboxamide hydrochloride
• CAS No.: 1078162-90-9
• Molecular Formula: C₁₁H₁₄N₂O*ClH
• Molecular Weight: 226.706
• Hs Code.: 2933990090
• Mol file: 1078162-90-9.mol

Synonyms:N-Phenyl-2-pyrrolidinecarboxamide hydrochloride

Chemical Property of N-Phenyl-2-pyrrolidinecarboxamide hydrochloride

Chemical Property:

• PSA: 41.13000
• LogP: 2.58090

Purity/Quality:

97% ^*data from raw suppliers

N-Phenylpyrrolidine-2-carboxamideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Phenyl-2-pyrrolidinecarboxamide hydrochloride

There total 7 articles about N-Phenyl-2-pyrrolidinecarboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl (S)-2-(phenylcarbamoyl)pyrrolidine-1-carboxylate (220510-58-7) → (S)-N-phenylpyrrolidine-2-carboxamide hydrochloride (1078162-90-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 15h;

DOI:10.1016/j.bmc.2021.116392

Reference yield:

C16H22N2O3 → C11H14N2O*ClH (1078162-90-9)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate; at 20 ℃;

DOI:10.1016/j.bioorg.2018.09.033

Reference yield:

aniline (62-53-3) → (S)-N-phenylpyrrolidine-2-carboxamide hydrochloride (1078162-90-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap

2: hydrogenchloride / ethyl acetate

With hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethyl acetate;

DOI:10.1111/cbdd.12661

upstream raw materials:

aniline

tert-butyl (S)-2-(phenylcarbamoyl)pyrrolidine-1-carboxylate

1-(tert-butoxycarbonyl)-L-proline

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