1,3-Piperidinedicarboxylic acid, 3-(phenylMethyl)-, 1-(1,1-diMethylethyl) ester, (3R)-

Base Information

• Chemical Name: 1,3-Piperidinedicarboxylic acid, 3-(phenylMethyl)-, 1-(1,1-diMethylethyl) ester, (3R)-
• CAS No.: 339539-81-0
• Molecular Formula: C18H25NO4
• Molecular Weight: 319.3954
• Mol file: 339539-81-0.mol

Synonyms:1,3-Piperidinedicarboxylic acid, 3-(phenylMethyl)-, 1-(1,1-diMethylethyl) ester, (3R)-;(R)-3-benzyl-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid;Anamorelin intermediate-2;(3R)-3-(Phenylmethyl)-1,3-piperidinedicarboxylic acid 1-(1,1-dimethylethyl) ester

Chemical Property of 1,3-Piperidinedicarboxylic acid, 3-(phenylMethyl)-, 1-(1,1-diMethylethyl) ester, (3R)-

Chemical Property:

• Boiling Point: 456.9±38.0 °C(Predicted)
• PKA: 4.40±0.20(Predicted)
• PSA: 66.84000
• Density: 1.167±0.06 g/cm3(Predicted)
• LogP: 3.26890
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

(R)-3-Benzyl-1-(tert-butoxycarbonyl)piperidine-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-Piperidinedicarboxylic acid, 3-(phenylMethyl)-, 1-(1,1-diMethylethyl) ester, (3R)-

There total 1 articles about 1,3-Piperidinedicarboxylic acid, 3-(phenylMethyl)-, 1-(1,1-diMethylethyl) ester, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (3R)-3-benzylpiperidine-1,3-dicarboxylic acid 1-tert-butyl ester (170838-87-6,339539-81-0)

Guidance literature:

Reference yield: 65.0%

N-Boc-3-benzylnipecotic acid (170838-87-6,339539-81-0) + Trimethylhydrazin (1741-01-1) → N-Boc-3-benzylnipecotic acid trimethylhydrazide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In tetrahydrofuran; at 20 ℃; for 48h; Reagent/catalyst; Solvent; Temperature;

DOI:10.1021/op0342022

Reference yield:

N,N,N'-trimethylhydrazine hydrochloride (60597-20-8,339539-94-5) + C18H25NO4 (170838-87-6,339539-81-0) → C21H33N3O3

Guidance literature:

C₁₈H₂₅NO₄; With oxalyl dichloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; at -20 - -15 ℃; for 5h; Inert atmosphere;

N,N,N'-trimethylhydrazine hydrochloride; With triethylamine; In 1,4-dioxane; at -20 ℃; for 21.5h;

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