2-(Difluoromethoxy)pyridine

Base Information

Chemical Name:2-(Difluoromethoxy)pyridine
CAS No.:865075-07-6
Molecular Formula:C₆H₅F₂NO
Molecular Weight:145.109
Hs Code.:
DSSTox Substance ID:DTXSID10705630
Wikidata:Q82638571
Mol file:865075-07-6.mol

Synonyms:2-(difluoromethoxy)pyridine;865075-07-6;difluoromethoxypyridine;SCHEMBL14357960;DTXSID10705630;AIIPLYODDSSCIA-UHFFFAOYSA-N;CS-0456513;J-506379

Suppliers and Price of 2-(Difluoromethoxy)pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
2-(Difluoromethoxy)pyridine 97%
250mg
$ 360.00

Crysdot
2-(Difluoromethoxy)pyridine 95+%
1g
$ 377.00

Chemenu
2-(difluoromethoxy)pyridine 95%
1g
$ 356.00

American Custom Chemicals Corporation
2-(DIFLUOROMETHOXY)PYRIDINE 95.00%
5MG
$ 500.02

Total 9 raw suppliers

Chemical Property of 2-(Difluoromethoxy)pyridine

Chemical Property:

PSA：22.12000
LogP:1.68300
Storage Temp.:2-8°C
XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:145.03392011
Heavy Atom Count:10
Complexity:99.7

Purity/Quality:

95+% ^*data from raw suppliers

2-(Difluoromethoxy)pyridine 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=NC(=C1)OC(F)F

Technology Process of 2-(Difluoromethoxy)pyridine

There total 4 articles about 2-(Difluoromethoxy)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 142-08-5
2-hydroxypyridin

: 667-27-6
Ethyl bromodifluoroacetate

: 865075-07-6
2-(difluoromethoxy)pyridine

Guidance literature:: With tert.-butylhydroperoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In water; acetonitrile; at 80 ℃; for 12h; Inert atmosphere; Schlenk technique;
DOI:10.1021/acs.joc.1c00228

Reference yield: 17.0%

: 142-08-5,1199357-22-6
2-Pyridone

: 65094-22-6
diethyl (bromodifluoromethyl)phosphonate

: 899452-34-7
1-(difluoromethyl)pyridin-2(1H)-one

: 865075-07-6
2-(difluoromethoxy)pyridine

Guidance literature:: 2-Pyridone; With potassium hydroxide; In water; acetonitrile; at 0 ℃; Sealed tube;

diethyl (bromodifluoromethyl)phosphonate; In water; acetonitrile; at 0 - 20 ℃; regioselective reaction; Sealed tube;
DOI:10.1016/j.jfluchem.2021.109867