tert-Butyl imidazolidine-1-carboxylate

Base Information

• Chemical Name: tert-Butyl imidazolidine-1-carboxylate
• CAS No.: 916891-97-9
• Molecular Formula: C8H16N2O2
• Molecular Weight: 172.227
• Hs Code.: 2933990090
• Mol file: 916891-97-9.mol

Synonyms:tert-Butyl imidazolidine-1-carboxylate

Chemical Property of tert-Butyl imidazolidine-1-carboxylate

Chemical Property:

• PSA: 41.57000
• LogP: 1.05090
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

95-99% ^*data from raw suppliers

tert-butylimidazolidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl imidazolidine-1-carboxylate

There total 2 articles about tert-Butyl imidazolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-benzylimidazolidine-1-carboxylic acid tert-butyl ester → tert-butyl imidazolidine-1-carboxylate (916891-97-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 6h; Inert atmosphere;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl imidazolidine-1-carboxylate (916891-97-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate; magnesium sulfate / chloroform / 18 h / 25 °C

1.2: 18 h / 25 °C

2.1: palladium on activated charcoal; hydrogen / ethanol / 16 h / 25 °C / 775.74 Torr

With palladium on activated charcoal; hydrogen; magnesium sulfate; potassium carbonate; In ethanol; chloroform;

Reference yield: 34.0%

tert-butyl imidazolidine-1-carboxylate (916891-97-9) + 2-chloro-N-(4-fluorophenyl)-6-(trifluoromethyl)pyrimidin-4-amine → tert-butyl 3-(4-((4-fluorophenyl)amino)-6-(trifluoromethyl)pyrimidin-2-yl)imidazolidine-1-carboxylate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 120 ℃; for 16h; Inert atmosphere; Sealed tube;

upstream raw materials:

di-tert-butyl dicarbonate

Refernces

• 1、 -. "HEPATITIS B VIRAL ASSEMBLY EFFECTORS". Paragraph 00319. . Retrieved 2016/10/31.