(8aR)-2,3,8,8a-tetrahydro-7(1H)-Indolizinone

Base Information

Chemical Name:(8aR)-2,3,8,8a-tetrahydro-7(1H)-Indolizinone
CAS No.:1260216-06-5
Molecular Formula:C₈H₁₁NO
Molecular Weight:137.181
Hs Code.:
Mol file:1260216-06-5.mol

Synonyms:(8aR)-2,3,8,8a-tetrahydro-7(1H)-Indolizinone

Suppliers and Price of (8aR)-2,3,8,8a-tetrahydro-7(1H)-Indolizinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (8aR)-2,3,8,8a-tetrahydro-7(1H)-Indolizinone

Chemical Property:

PSA：20.31000
LogP:0.87520

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (8aR)-2,3,8,8a-tetrahydro-7(1H)-Indolizinone

There total 5 articles about (8aR)-2,3,8,8a-tetrahydro-7(1H)-Indolizinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1240530-39-5
(S)-tert-butyl 2-(2-oxobut-3-yn-1-yl)pyrrolidine-1-carboxylate

: 1240530-56-6
(S)-2,3,8,8a-tetrahydroindolizin-7(1H)-one

: 1260216-06-5
(R)-2,3,8,8a-tetrahydroindolizin-7(1H)-one

Guidance literature:: (S)-tert-butyl 2-(2-oxobut-3-yn-1-yl)pyrrolidine-1-carboxylate; With hydrogenchloride; In 1,4-dioxane; water; for 0.25h;

With potassium carbonate; In methanol; for 1h; optical yield given as %ee;
DOI:10.1021/jo100907u

Reference yield:

: 1202039-17-5
N-methoxy-N-methyl (R)-2-[N(1')-(tert-butoxycarbonyl)-pyrrolidin-2'-yl]ethanamide

: 1260216-06-5
(R)-2,3,8,8a-tetrahydroindolizin-7(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 0 - 20 °C

2: formic acid; sodium iodide / 6 h / 20 °C / Inert atmosphere

3: methanol; potassium carbonate / 1.25 h

With methanol; formic acid; potassium carbonate; sodium iodide; In tetrahydrofuran;
DOI:10.1021/ol1023954

Reference yield:

: 101555-60-6
2-(R)-carboxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1260216-06-5
(R)-2,3,8,8a-tetrahydroindolizin-7(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C / Inert atmosphere

2: tetrahydrofuran / 0 - 20 °C

3: formic acid; sodium iodide / 6 h / 20 °C / Inert atmosphere

4: methanol; potassium carbonate / 1.25 h

With 4-methyl-morpholine; methanol; formic acid; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium iodide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol1023954