Technology Process of (7R,9R)-5-Ethyl-1,4,7,8,9,10-hexahydro-2H-3,7-methanoazacycloundecino[5,4-b]indole-9-carboxylic acid methyl ester
There total 5 articles about (7R,9R)-5-Ethyl-1,4,7,8,9,10-hexahydro-2H-3,7-methanoazacycloundecino[5,4-b]indole-9-carboxylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
catharanthine sulfate;
With
trifluoroacetic acid;
at 20 ℃;
for 36h;
With
sodium tetrahydroborate;
In
tetrahydrofuran;
at 0 ℃;
for 0.166667h;
Further stages. Title compound not separated from byproducts.;
DOI:10.1021/jo0202942
- Guidance literature:
-
Multi-step reaction with 2 steps
1: p-nitroperoxybenzoic acid / CH2Cl2
2: 1) trifluoroacetic acid (TFAA), 2) NaBH4 / 1a) -40 deg C, 1 h, 1b) 0 deg C, 3 h
With
sodium tetrahydroborate; p-nitroperoxybenzoic acid; trifluoroacetic acid;
In
dichloromethane;
DOI:10.1016/S0040-4020(01)88140-0
- Guidance literature:
-
With
sodium tetrahydroborate; trifluoroacetic acid;
Multistep reaction;
1a) -40 deg C, 1 h, 1b) 0 deg C, 3 h;
DOI:10.1016/S0040-4020(01)88140-0
