2-bromomethyl-5-thiazolecarboxylic acid ethyl ester

Base Information

• Chemical Name: 2-bromomethyl-5-thiazolecarboxylic acid ethyl ester
• CAS No.: 173089-24-2
• Molecular Weight: 250.11
• Mol file: 173089-24-2.mol

Synonyms:2-bromomethyl-5-thiazolecarboxylic acid ethyl ester;Ethyl 2-(bromomethyl)thiazole-5-carboxylate

Chemical Property of 2-bromomethyl-5-thiazolecarboxylic acid ethyl ester

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% min ^*data from raw suppliers

Ethyl2-(bromomethyl)thiazole-5-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromomethyl-5-thiazolecarboxylic acid ethyl ester

There total 7 articles about 2-bromomethyl-5-thiazolecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

ethyl 2-methylthiazole-5-carboxylate (79836-78-5) → 2-bromomethylthiazole-5-carboxylic acid ethyl ester (173089-24-2)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 2h; UV-irradiation;

DOI:10.1246/cl.2012.1560

Reference yield:

ethyl 2-(dibromomethyl)selenazole-5-carboxylate → 2-bromomethylthiazole-5-carboxylic acid ethyl ester (173089-24-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; phosphonic acid diethyl ester; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

DOI:10.1039/c4cc04460f

Reference yield:

ethyl 2-(dibromomethyl)thiazole-5-carboxylate → 2-bromomethylthiazole-5-carboxylic acid ethyl ester (173089-24-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; phosphonic acid diethyl ester; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

DOI:10.1039/c4cc04460f

upstream raw materials:

ethyl 2-methylthiazole-5-carboxylate

ethyl 2-chloro-3-oxopropanoate