2-(Aminomethyl)-6-phenylpyridine

Base Information

• Chemical Name: 2-(Aminomethyl)-6-phenylpyridine
• CAS No.: 162614-74-6
• Molecular Formula: C₁₂H₁₂N₂
• Molecular Weight: 184.241
• Mol file: 162614-74-6.mol

Synonyms:2-(Aminomethyl)-6-phenylpyridine

Chemical Property of 2-(Aminomethyl)-6-phenylpyridine

Chemical Property:

• PSA: 38.91000
• LogP: 2.90760

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Aminomethyl)-6-phenylpyridine

There total 5 articles about 2-(Aminomethyl)-6-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(phthalimidomethyl)-6-phenylpyridine (162614-71-3) → (6-phenyl-2-pyridyl)methylamine (162614-74-6)

Guidance literature:

With hydrazine hydrate; In ethanol; for 2h; Heating;

DOI:10.1039/b413683g

Reference yield:

6-phenyl-2-picolinaldoxime → (6-phenyl-2-pyridyl)methylamine (162614-74-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 10h; Inert atmosphere; Reflux;

DOI:10.1039/c1dt10331h

Reference yield:

6-bromo-2-pyridinecarbaldehyde (34160-40-2) → (6-phenyl-2-pyridyl)methylamine (162614-74-6)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / Reflux

2: hydroxylamine hydrochloride / methanol / 4 h / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 10 h / Inert atmosphere; Reflux

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; In tetrahydrofuran; methanol; toluene; 1: Suzuki coupling;

DOI:10.1039/c1dt10331h

upstream raw materials:

2-(phthalimidomethyl)-6-phenylpyridine

6-bromo-2-pyridinecarbaldehyde

6-phenylpyridine-2-carbaldehyde

phenylboronic acid

Downstream raw materials:

[RuCl(2-aminomethyl-6-phenylpyridine(-H))(1,4-bis(diphenylphosphino)butane)]*dichloromethane

Refernces

• 1、 Rudzka, Katarzyna,Makowska-Grzyska, Magdalena M.,Szajna, Ewa,Arif, Atta M.,Berreau, Lisa M.. "Neutral acetohydroxamic acid coordination to a mononuclear Ni(II) center stabilized by an intramolecular hydrogen-bonding interaction". . p. 489 - 491. Retrieved 2008/09/18.