4-O-DeMethylisokadsurenin D

Base Information

• Chemical Name: 4-O-DeMethylisokadsurenin D
• CAS No.: 89104-59-6
• Molecular Formula: C₂₀H₂₂O₅
• Molecular Weight: 342.392
• Mol file: 89104-59-6.mol

Synonyms:4-O-DeMethylisokadsurenin D;(6-exo,7-endo)-7-(4-Hydroxy-3-methoxyphenyl)-3-methoxy-6-methyl-5-(2-propenyl)bicyclo[3.2.1]oct-3-ene-2,8-dione

Chemical Property of 4-O-DeMethylisokadsurenin D

Chemical Property:

• Boiling Point: 519.7±50.0 °C(Predicted)
• PKA: 7.92±0.70(Predicted)
• PSA: 72.83000
• Density: 1.24±0.1 g/cm3(Predicted)
• LogP: 2.99490

Purity/Quality:

>95% ^*data from raw suppliers

4-O-DemethylisokadsureninD 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-O-DeMethylisokadsurenin D

There total 8 articles about 4-O-DeMethylisokadsurenin D which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(+/-)-(2β,3α,3aα)-2-<4-<(tert-butyldimethylsilyl)oxy>-3-methoxyphenyl>-3,3a-dihydro-5-methoxy-3-methyl-3a-(2-propenyl)-6(2H)-benzofuranone (127086-32-2,127102-26-5) → (+/-)-(6-exo,7-endo)-7-(4-hydroxy-3-methoxyphenyl)-3-methoxy-6-methyl-5-(2-propenyl)bicyclo<3.2.1>oct-3-ene-2,8-dione (65527-31-3,74560-01-3,89104-59-6,112318-82-8,127179-70-8,127180-73-8)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; Ambient temperature;

DOI:10.1021/jo00072a017

Reference yield: 89.0%

(+/-)-(2β,3β,3aα)-2-<4-<(tert-butyldimethylsilyl)oxy>-3-methoxyphenyl>-3,3a-dihydro-5-methoxy-3-methyl-3a-(2-propenyl)-6(2H)-benzofuranone (127086-32-2,127102-26-5) → (+/-)-(6-endo,7-exo)-7-(4-hydroxy-3-methoxyphenyl)-3-methoxy-6-methyl-5-(2-propenyl)bicyclo<3.2.1>oct-3-ene-2,8-dione (65527-31-3,74560-01-3,89104-59-6,112318-82-8,127179-70-8,127180-73-8)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.5h; Ambient temperature;

DOI:10.1021/jo00072a017

Reference yield:

(Z)-1-<(tert-butyldimethylsilyl)oxy>-2-methoxy-4-(1-propenyl)benzene (127086-31-1) → (+/-)-(6-endo,7-exo)-7-(4-hydroxy-3-methoxyphenyl)-3-methoxy-6-methyl-5-(2-propenyl)bicyclo<3.2.1>oct-3-ene-2,8-dione (65527-31-3,74560-01-3,89104-59-6,112318-82-8,127179-70-8,127180-73-8)

Guidance literature:

Multi-step reaction with 2 steps

2: (n-Bu)4NF / tetrahydrofuran / -95 - 80 °C / var. fluoride, var. solvents, other benzofuranones

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1021/ja00165a087

upstream raw materials:

(+/-)-(2β,3β,3aα)-2-<4-<(tert-butyldimethylsilyl)oxy>-3-methoxyphenyl>-3,3a-dihydro-5-methoxy-3-methyl-3a-(2-propenyl)-6(2H)-benzofuranone

(Z)-1-<(tert-butyldimethylsilyl)oxy>-2-methoxy-4-(1-propenyl)benzene

(+/-)-(2β,3α,3aα)-2-<4-<(tert-butyldimethylsilyl)oxy>-3-methoxyphenyl>-3,3a-dihydro-5-methoxy-3-methyl-3a-(2-propenyl)-6(2H)-benzofuranone

(1R,5R,6R,7R)-5-Allyl-3-methoxy-7-[3-methoxy-4-(4-methoxy-benzyloxy)-phenyl]-6-methyl-bicyclo[3.2.1]oct-3-ene-2,8-dione