Benzonitrile, 4-(3-hydroxy-1-piperidinyl)-

Base Information

Chemical Name:Benzonitrile, 4-(3-hydroxy-1-piperidinyl)-
CAS No.:186651-01-4
Molecular Formula:C₁₂H₁₄N₂O
Molecular Weight:202.256
Hs Code.:
European Community (EC) Number:858-212-1

Synonyms:186651-01-4;4-(3-hydroxypiperidin-1-yl)benzonitrile;Benzonitrile, 4-(3-hydroxy-1-piperidinyl)-;4-(3-Hydroxy-piperidin-1-yl)-benzonitrile;4-(3-Hydroxypiperidin-1-yl)-benzonitrile;SCHEMBL14637983;4-(3-hydroxypiperidino)benzonitrile;AKOS009093407;FT-0770323;EN300-6730770;A1-04004

Suppliers and Price of Benzonitrile, 4-(3-hydroxy-1-piperidinyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of Benzonitrile, 4-(3-hydroxy-1-piperidinyl)-

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:202.110613074
Heavy Atom Count:15
Complexity:250

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC(CN(C1)C2=CC=C(C=C2)C#N)O

Technology Process of Benzonitrile, 4-(3-hydroxy-1-piperidinyl)-

There total 1 articles about Benzonitrile, 4-(3-hydroxy-1-piperidinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6859-99-0
3-hydroxypiperazine

: 1194-02-1,143234-87-1
4-fluorobenzonitrile

: 186651-01-4
4-(3-hydroxypiperidin-1-yl)benzonitrile

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide;
DOI:10.1016/0960-894X(96)00373-3

Reference yield: 95.0%

: 186651-01-4
4-(3-hydroxypiperidin-1-yl)benzonitrile

: 1027185-58-5
4-(3-oxopiperidin-1-yl)benzonitrile

Guidance literature:: 4-(3-hydroxypiperidin-1-yl)benzonitrile; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 2.16667h;

With triethylamine; In dichloromethane; at 0 ℃; for 0.333333h;

Reference yield:

: 186651-01-4
4-(3-hydroxypiperidin-1-yl)benzonitrile

: C₂₀H₁₉N₃

Guidance literature:: Multi-step reaction with 3 steps

1.1: DMSO; DCC; TFA / pyridine / benzene / 24 h / 20 °C

2.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

2.2: tetrahydrofuran / Heating

3.1: H₂ / 5percent Pd/C / methanol

With hydrogen; sodium hydride; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; pyridine; In tetrahydrofuran; methanol; benzene; 2.2: Wittig reaction;
DOI:10.1021/jm020375q