N,N'-Diacetylglycine anhydride

Base Information

• Chemical Name: N,N'-Diacetylglycine anhydride
• CAS No.: 3027-05-2
• Molecular Formula: C8H10N2O4
• Molecular Weight: 198.178
• Hs Code.: 2933599090
• Mol file: 3027-05-2.mol

Synonyms:2,5-Piperazinedione, 1,4-diacetyl-;1,4-Diacetyl-piperazine-2,5-dione;

Chemical Property of N,N'-Diacetylglycine anhydride

Chemical Property:

• Melting Point: 99-100 °C
• Boiling Point: 424.4 °C at 760 mmHg
• PKA: -1.74±0.20(Predicted)
• Flash Point: 216.6 °C
• PSA: 74.76000
• Density: 1.375 g/cm³
• LogP: -1.37400
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

N,N'-Diacetylglycine Anhydride >98.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-43-36/38-22
• Safety Statements: 26-36/37/39-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of N,N'-Diacetylglycine anhydride

There total 7 articles about N,N'-Diacetylglycine anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

Glycine anhydride (106-57-0) + acetic anhydride (108-24-7) → N,N'-diacetylpiperazin-2,5-dione (3027-05-2)

Guidance literature:

for 7h; Reflux;

DOI:10.1016/j.bmc.2021.116462

Reference yield:

PVS (5535-48-8) + 1,4-Diacetyl-3-bromopiperazine-2,5-dione (153074-39-6) → N,N'-diacetylpiperazin-2,5-dione (3027-05-2) + 1,4-Diacetyl-3-(2-benzenesulfonyl-ethyl)-piperazine-2,5-dione

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; Ambient temperature; Irradiation;

DOI:10.1016/S0040-4039(00)79356-7

Reference yield:

Glycine anhydride (106-57-0) → N,N'-diacetylpiperazin-2,5-dione (3027-05-2)

Guidance literature:

In acetic anhydride (Ac₂O); ethyl acetate;

upstream raw materials:

Glycine anhydride

acetic anhydride

PVS

1,4-Diacetyl-3-bromopiperazine-2,5-dione

Downstream raw materials:

1-acetyl-3-((Z)-2,2,4-trimethyl-[1,3]dioxolan-4-ylmethylene)-piperazine-2,5-dione

(5S)-4c-(4-bromo-benzoyloxy)-3c-hydroxy-3t-methyl-12-methylene-(5rN,5r'O,8c'O)-1,9-dioxa-6,13-diaza-dispiro[4.2.4.2]tetradecane-7,14-dione

(5S)-4c-(4-bromo-benzoyloxy)-3c-hydroxy-3t-methyl-12-methylene-(5rN,5r'O,8t'O)-1,9-dioxa-6,13-diaza-dispiro[4.2.4.2]tetradecane-7,14-dione

(Z)-1-acetyl-3-(5-chloro-2-hydroxy-4-methoxy)benzylidene-2,5-piperazinedione

Refernces

• 1、 Wieczorek, Anna,Plazuk, Damian,Zakrzewski, Janusz,Makal, Anna,Wo?niak, Krzysztof. "Synthesis and unusual ring transformation of 1-acyl-3- (ferrocenylmethylidene)-piperazine-2,5-diones". . p. 373 - 378. Retrieved 2013.
• 2、 Chai,Page. "Radical addition of simple piperazine-2,5-diones". . p. 4373 - 4376. Retrieved 1993.
• 3、 Falkenstein, Markus,Reiner-Link, David,Zivkovic, Aleksandra,Gering, Ian,Willbold, Dieter,Stark, Holger. "Histamine H3 receptor antagonists with peptidomimetic (keto)piperazine structures to inhibit Aβ oligomerisation". . . Retrieved 2021/10/29.
• 4、 Xiao, Guiying,Xu, Shuang,Xie, Chaochao,Zi, Guofu,Ye, Weiping,Zhou, Zhangtao,Hou, Guohua,Zhang, Zhanbin. "Enantioselective Synthesis of Chiral Substituted 2,4-Diketoimidazolidines and 2,5-Diketopiperazines via Asymmetric Hydrogenation". supporting information. p. 5734 - 5738. Retrieved 2021/08/01.