Methyl 3-[2-(4-chlorophenyl)-5-oxo-4,5-dihydro-1H-pyrrol-3-yl]propanoate

Base Information

Chemical Name:Methyl 3-[2-(4-chlorophenyl)-5-oxo-4,5-dihydro-1H-pyrrol-3-yl]propanoate
CAS No.:198063-87-5
Molecular Formula:C14H14ClNO3
Molecular Weight:300.141
Hs Code.:2933990090
Mol file:198063-87-5.mol

Synonyms:Methyl 3-[2-(4-chlorophenyl)-5-oxo-4,5-dihydro-1H-pyrrol-3-yl]propanoate

Suppliers and Price of Methyl 3-[2-(4-chlorophenyl)-5-oxo-4,5-dihydro-1H-pyrrol-3-yl]propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
Methyl 3-[2-(4-chlorophenyl)-5-oxo-4,5-dihydro-1H-pyrrol-3-yl]propanoate >97%
500mg
$ 408.00

Crysdot
Methyl3-(2-(4-chlorophenyl)-5-oxo-4,5-dihydro-1H-pyrrol-3-yl)propanoate 95+%
1g
$ 430.00

Apolloscientific
Methyl3-[2-(4-chlorophenyl)-5-oxo-4,5-dihydro-1H-pyrrol-3-yl]propanoate
500mg
$ 241.00

AK Scientific
Methyl3-[2-(4-chlorophenyl)-5-oxo-4,5-dihydro-1H-pyrrol-3-yl]propanoate
500mg
$ 600.00

Total 2 raw suppliers

Chemical Property of Methyl 3-[2-(4-chlorophenyl)-5-oxo-4,5-dihydro-1H-pyrrol-3-yl]propanoate

Chemical Property:

PSA：55.40000
LogP:2.85300

Purity/Quality:

97% ^*data from raw suppliers

Methyl 3-[2-(4-chlorophenyl)-5-oxo-4,5-dihydro-1H-pyrrol-3-yl]propanoate >97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Methyl 3-[2-(4-chlorophenyl)-5-oxo-4,5-dihydro-1H-pyrrol-3-yl]propanoate

There total 7 articles about Methyl 3-[2-(4-chlorophenyl)-5-oxo-4,5-dihydro-1H-pyrrol-3-yl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 198064-81-2
methyl 3-[4-(4-chlorophenyl)-2-oxo-2,3-dihydro-5-oxazolyl]propionate

: 198063-87-5
methyl 3-[2-chloro-4-(4-chlorophenyl)-5-oxazolyl]propionate

Guidance literature:: With pyridine; trichlorophosphate; at 125 ℃; for 1.5h;
DOI:10.1248/cpb.51.565

Reference yield:

: 1501-26-4
methyl 4-(chlorocarbonyl)butyrate

: 198063-87-5
methyl 3-[2-chloro-4-(4-chlorophenyl)-5-oxazolyl]propionate

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / AlCl₃ / 2 h / 20 °C

2: 88 percent / Br₂ / CH₂Cl₂ / 20 °C

3: HCO₂Na / methanol / 12 h / Heating

4: 61.2 g / pyridine / tetrahydrofuran / 1 h / 20 °C

5: 79 percent / NH₄OAc; AcOH / 2 h / Heating

6: 73 percent / POCl₃; pyridine / 1.5 h / 125 °C

With pyridine; aluminium trichloride; ammonium acetate; bromine; sodium formate; acetic acid; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; 1: Friedel-Crafts reaction;
DOI:10.1248/cpb.51.565

Reference yield:

: 71354-29-5
methyl 5-(4-chlorophenyl)-5-oxopentanoate

: 198063-87-5
methyl 3-[2-chloro-4-(4-chlorophenyl)-5-oxazolyl]propionate

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / Br₂ / CH₂Cl₂ / 20 °C

2: HCO₂Na / methanol / 12 h / Heating

3: 61.2 g / pyridine / tetrahydrofuran / 1 h / 20 °C

4: 79 percent / NH₄OAc; AcOH / 2 h / Heating

5: 73 percent / POCl₃; pyridine / 1.5 h / 125 °C

With pyridine; ammonium acetate; bromine; sodium formate; acetic acid; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1248/cpb.51.565