1-Azabicyclo[3.2.0]heptane-2-carboxaldehyde,3,3-dimethyl-7-oxo-,cis-(9CI)

Base Information

Chemical Name:1-Azabicyclo[3.2.0]heptane-2-carboxaldehyde,3,3-dimethyl-7-oxo-,cis-(9CI)
CAS No.:81310-19-2
Molecular Formula:C₉H₁₃NO₂
Molecular Weight:167.208
Hs Code.:
Mol file:81310-19-2.mol

Synonyms:1-Azabicyclo[3.2.0]heptane-2-carboxaldehyde,3,3-dimethyl-7-oxo-,cis-(9CI)

Suppliers and Price of 1-Azabicyclo[3.2.0]heptane-2-carboxaldehyde,3,3-dimethyl-7-oxo-,cis-(9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Azabicyclo[3.2.0]heptane-2-carboxaldehyde,3,3-dimethyl-7-oxo-,cis-(9CI)

Chemical Property:

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Technology Process of 1-Azabicyclo[3.2.0]heptane-2-carboxaldehyde,3,3-dimethyl-7-oxo-,cis-(9CI)

There total 9 articles about 1-Azabicyclo[3.2.0]heptane-2-carboxaldehyde,3,3-dimethyl-7-oxo-,cis-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 81310-17-0,81310-18-1
(R)-3,3-Dimethyl-2-nitromethyl-1-aza-bicyclo[3.2.0]heptan-7-one

: 81310-19-2
(2R,5R)-3,3-Dimethyl-7-oxo-1-aza-bicyclo[3.2.0]heptane-2-carbaldehyde

Guidance literature:: With ozone; 1,2,3,4,4a,5,6,7-octahydro-2,2,4a,7,7-pentametyl-1,8-naphthyridene; In methanol; at -60 ℃;
DOI:10.1016/S0040-4039(01)82981-6

Reference yield:

: 7796-73-8
3,3-dimethylpent-4-enoic acid

: 81310-19-2
(2R,5R)-3,3-Dimethyl-7-oxo-1-aza-bicyclo[3.2.0]heptane-2-carbaldehyde

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) SOCl₂ / 1.) reflux 2.) -78 deg C, THF

2: 90 percent / NH₂OH_.HCl / pyridine / 50 °C

3: 1.) Na 2.) HCl / 1.) i-PrOH, reflux 2.) Room temp.

4: 55 percent / mesitylmagnesium bromide / CH₂Cl₂ / Ambient temperature

5: 1.) N,N-diisopropylethylamine 2.) O₃ / 1.) DMF, 0 deg C 2.) Me OH, -30 deg C, Me₂S, R_.T_.

6: 85 percent / various solvent(s)

7: 72 percent / Ac₂O / pyridine / Ambient temperature

8: HCl / methanol / 0 °C

9: 62 percent / 3,36,9,9-pentamethyl-2,10-diaza-bicyclo-4.4.o>-1-decene, O₃ / methanol / -60 °C

With hydrogenchloride; thionyl chloride; hydroxylamine hydrochloride; sodium; acetic anhydride; ozone; N-ethyl-N,N-diisopropylamine; 1,2,3,4,4a,5,6,7-octahydro-2,2,4a,7,7-pentametyl-1,8-naphthyridene; 2-mesitylmagnesium bromide; hydrogenchloride; In pyridine; methanol; dichloromethane;
DOI:10.1016/S0040-4039(01)82981-6

Reference yield:

: 81310-14-7
4-(2,2-Dimethyl-but-3-enyl)-azetidin-2-one

: 81310-19-2
(2R,5R)-3,3-Dimethyl-7-oxo-1-aza-bicyclo[3.2.0]heptane-2-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) N,N-diisopropylethylamine 2.) O₃ / 1.) DMF, 0 deg C 2.) Me OH, -30 deg C, Me₂S, R_.T_.

2: 85 percent / various solvent(s)

3: 72 percent / Ac₂O / pyridine / Ambient temperature

4: HCl / methanol / 0 °C

5: 62 percent / 3,36,9,9-pentamethyl-2,10-diaza-bicyclo-4.4.o>-1-decene, O₃ / methanol / -60 °C

With acetic anhydride; ozone; N-ethyl-N,N-diisopropylamine; 1,2,3,4,4a,5,6,7-octahydro-2,2,4a,7,7-pentametyl-1,8-naphthyridene; hydrogenchloride; In pyridine; methanol;
DOI:10.1016/S0040-4039(01)82981-6