(R)-4-Boc-2-((R)-hydroxy(phenyl)Methyl)Morpholine

Base Information

Chemical Name:(R)-4-Boc-2-((R)-hydroxy(phenyl)Methyl)Morpholine
CAS No.:868685-97-6
Molecular Formula:C16H23NO4
Molecular Weight:293.35812
Hs Code.:
Mol file:868685-97-6.mol

Synonyms:(R)-4-Boc-2-((R)-hydroxy(phenyl)Methyl)Morpholine;(2R)-2-[(R)-Hydroxyphenylmethyl]-4-morpholinecarboxylic acid 1,1-dimethylethyl ester

Suppliers and Price of (R)-4-Boc-2-((R)-hydroxy(phenyl)Methyl)Morpholine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of (R)-4-Boc-2-((R)-hydroxy(phenyl)Methyl)Morpholine

Chemical Property:

PSA：59.00000
LogP:2.29380

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (R)-4-Boc-2-((R)-hydroxy(phenyl)Methyl)Morpholine

There total 10 articles about (R)-4-Boc-2-((R)-hydroxy(phenyl)Methyl)Morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 869088-60-8
C₁₆H₂₁NO₄

: 868685-97-6
(2R,3R)-2-(α-hydroxyphenylmethyl)morpholine-4-carboxylic acid t-butyl ester

: 1030837-58-1
(2R,3S)-2-(α-hydroxyphenylmethyl)morpholine-4-carboxylic acid t-butyl ester

Guidance literature:: With zinc(II) tetrahydroborate; In diethyl ether; at 20 ℃;
DOI:10.1016/j.bmcl.2008.03.050

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1190855-52-7
(2R,3R)-2-[α-hydroxyphenylmethyl]morpholine-5-one

: 868685-97-6
(2R,3R)-2-(α-hydroxyphenylmethyl)morpholine-4-carboxylic acid t-butyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1016/j.bmcl.2009.07.064

Reference yield:

: 130115-07-0
(R)-2-(t-butyldimethylsilyloxy)-2-phenylacetaldehyde

: 868685-97-6
(2R,3R)-2-(α-hydroxyphenylmethyl)morpholine-4-carboxylic acid t-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: (1S,2R)-1,2-diphenyl-2-piperidin-1-ylethanol; copper(II) acetate monohydrate / 72 h / 20 °C

2: hydrogenchloride / methanol; water / 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 7600.51 Torr

4: potassium carbonate / 1 h / 0 °C

5: potassium tert-butylate / tert-butyl alcohol / 2 h / 20 °C

6: lithium aluminium tetrahydride / tetrahydrofuran / 6 h / 0 °C / Reflux

7: tetrahydrofuran / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; palladium 10% on activated carbon; (1S,2R)-1,2-diphenyl-2-piperidin-1-ylethanol; potassium tert-butylate; hydrogen; copper(II) acetate monohydrate; potassium carbonate; In tetrahydrofuran; methanol; water; tert-butyl alcohol; 1: |Henry Nitro Aldol Condensation;
DOI:10.1039/c7ob01283g