4-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

Base Information

Chemical Name:4-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
CAS No.:1137278-45-5
Molecular Formula:C₁₂H₁₃ClN₂O
Molecular Weight:236.701
Hs Code.:2934999090
Mol file:1137278-45-5.mol

Synonyms:4-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole;1H-Indazole, 4-chloro-1-(tetrahydro-2H-pyran-2-yl)-;4-chloro-1-(oxan-2-yl)indazole

Suppliers and Price of 4-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
4-chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole 95%
1g
$ 580.00

American Custom Chemicals Corporation
4-CHLORO-1-(TETRAHYDRO-2H-PYRAN-2-YL)-1H-INDAZOLE 95.00%
5MG
$ 499.86

Alichem
4-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
1g
$ 490.00

Total 6 raw suppliers

Chemical Property of 4-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

Chemical Property:

Melting Point:55-56 °C
Boiling Point:386.5±32.0 °C(Predicted)
PKA:-0.18±0.30(Predicted)
PSA：27.05000
Density:1.37±0.1 g/cm3(Predicted)
LogP:3.38880

Purity/Quality:

≥95% ^*data from raw suppliers

4-chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

There total 3 articles about 4-Chloro-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 13096-96-3
4-chloro-1H-indazole

: 1137278-45-5,956388-06-0,956387-86-3
4-chloro-1-(tetrahydro-2H-pyran-2-yl)-2H-indazole

Guidance literature:: With trifluoroacetic acid; In ethyl acetate; for 2.5h; Inert atmosphere; Reflux;
DOI:10.1021/jacs.7b08979

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 13096-96-3
4-chloro-1H-indazole

: 1137278-45-5,956388-06-0,956387-86-3
4-chloro-1-(tetrahydro-2H-pyran-2-yl)-2H-indazole

: 1146955-34-1
4-chloro-2-(tetrahydro-2H-pyran-2-yl)-2H-indazole

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; at 45 ℃; for 8h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 87-60-5
3-chloro-2-methylbenzenamine

: 1137278-45-5,956388-06-0,956387-86-3
4-chloro-1-(tetrahydro-2H-pyran-2-yl)-2H-indazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium acetate / chloroform / 0 °C

1.2: 1 h / 25 °C

2.1: pyridinium p-toluenesulfonate / dichloromethane / 16 h / 45 °C

With potassium acetate; pyridinium p-toluenesulfonate; In dichloromethane; chloroform;