3-Chloro-5-(4-chloro-phenyl)-4-(2,6-difluoro-phenyl)-6-methyl-pyridazine

Base Information

• Chemical Name: 3-Chloro-5-(4-chloro-phenyl)-4-(2,6-difluoro-phenyl)-6-methyl-pyridazine
• CAS No.: 871513-21-2
• Molecular Formula: C₁₇H₁₀Cl₂F₂N₂
• Molecular Weight: 351.183
• Mol file: 871513-21-2.mol

Synonyms:3-Chloro-5-(4-chloro-phenyl)-4-(2,6-difluoro-phenyl)-6-methyl-pyridazine

Chemical Property of 3-Chloro-5-(4-chloro-phenyl)-4-(2,6-difluoro-phenyl)-6-methyl-pyridazine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 412.714°C at 760 mmHg
• Flash Point: 203.402°C
• PSA: 25.78000
• Density: 1.377g/cm³
• LogP: 5.70400

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Chloro-5-(4-chloro-phenyl)-4-(2,6-difluoro-phenyl)-6-methyl-pyridazine

There total 2 articles about 3-Chloro-5-(4-chloro-phenyl)-4-(2,6-difluoro-phenyl)-6-methyl-pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(4-chlorophenyl)-4-(2,6-difluorophenyl)-6-methyl-2H-pyridazin-3-one (871513-60-9) → 3-chloro-5-(4-chlorophenyl)-4-(2,6-difluorophenyl)-6-methylpyridazine (871513-21-2)

Guidance literature:

With trichlorophosphate; at 110 ℃; for 4h;

Reference yield:

3-(4-chlorophenyl)-2-(2,6-difluorophenyl)-2-hydroxy-4-oxopentanoic acid → 3-chloro-5-(4-chlorophenyl)-4-(2,6-difluorophenyl)-6-methylpyridazine (871513-21-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate; acetic acid / butan-1-ol / 12 h / Reflux

2: trichlorophosphate / 4 h / 110 °C

With hydrazine hydrate; acetic acid; trichlorophosphate; In butan-1-ol;

upstream raw materials:

5-(4-chlorophenyl)-4-(2,6-difluorophenyl)-6-methyl-2H-pyridazin-3-one