(R)-2-(3-CHLORO-4-METHANESULFONYLPHENYL)-3-(2-OXOCYCLOPENTYL)PROPIONIC ACID

Base Information

Chemical Name:(R)-2-(3-CHLORO-4-METHANESULFONYLPHENYL)-3-(2-OXOCYCLOPENTYL)PROPIONIC ACID
CAS No.:625113-52-2
Molecular Formula:C15H17ClO5S
Molecular Weight:344.816
Hs Code.:2918300090
Mol file:625113-52-2.mol

Synonyms:(R)-2-(3-CHLORO-4-METHANESULFONYLPHENYL)-3-(2-OXOCYCLOPENTYL)PROPIONIC ACID

Suppliers and Price of (R)-2-(3-CHLORO-4-METHANESULFONYLPHENYL)-3-(2-OXOCYCLOPENTYL)PROPIONIC ACID

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(2R)-2-(3-Chloro-4-(methylsulfonyl)phenyl)-3-(2-oxocyclopentyl)propanoicacid 97%
1g
$ 875.00

American Custom Chemicals Corporation
(R)-2-(3-CHLORO-4-METHANESULFONYLPHENYL)-3-(2-OXOCYCLOPENTYL)PROPIONIC ACID 95.00%
1G
$ 1358.28

Alichem
(R)-2-(3-Chloro-4-methanesulfonylphenyl)-3-(2-oxocyclopentyl)propionicacid
250mg
$ 409.20

Alichem
(R)-2-(3-Chloro-4-methanesulfonylphenyl)-3-(2-oxocyclopentyl)propionicacid
1g
$ 985.80

AK Scientific
(R)-2-(3-Chloro-4-methanesulfonylphenyl)-3-(2-oxocyclopentyl)propionicacid
250mg
$ 577.00

Total 7 raw suppliers

Chemical Property of (R)-2-(3-CHLORO-4-METHANESULFONYLPHENYL)-3-(2-OXOCYCLOPENTYL)PROPIONIC ACID

Chemical Property:

PSA：96.89000
LogP:3.75180

Purity/Quality:

97% ^*data from raw suppliers

(2R)-2-(3-Chloro-4-(methylsulfonyl)phenyl)-3-(2-oxocyclopentyl)propanoicacid 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (R)-2-(3-CHLORO-4-METHANESULFONYLPHENYL)-3-(2-OXOCYCLOPENTYL)PROPIONIC ACID

There total 15 articles about (R)-2-(3-CHLORO-4-METHANESULFONYLPHENYL)-3-(2-OXOCYCLOPENTYL)PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: (2R)-2-(3-chloro-4-methanesulfinylphenyl)-3-(2-oxocyclopentyl)propanoic acid

: 625113-52-2
(2R)-2-(3-chloro-4-methanesulfonylphenyl)-3-(2-oxocyclopentyl)propanoic acid

Guidance literature:: With potassium permanganate; In methanol; water; at 25 ℃; for 1h;

Reference yield:

: 17733-22-1
2-chlorothioanisole

: 625113-52-2
(2R)-2-(3-chloro-4-methanesulfonylphenyl)-3-(2-oxocyclopentyl)propanoic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: aluminum (III) chloride / chloroform / 0.5 h / 0 °C / Inert atmosphere

1.2: 4 h / 0 - 20 °C / Inert atmosphere

2.1: sodium hydroxide; water / toluene / 1.5 h / 50 - 60 °C / Inert atmosphere

3.1: hydrazine hydrate; potassium hydroxide / 16 h / -50 - 100 °C / Inert atmosphere

4.1: potassium carbonate; pivaloyl chloride / acetone / 0.33 h / -10 - 20 °C / Inert atmosphere

5.1: lithium hexamethyldisilazane; n-butyllithium / hexane; tetrahydrofuran / 1 h / -45 - 0 °C / Inert atmosphere

5.2: 3 h / -45 - 0 °C / Inert atmosphere

6.1: pyridinium p-toluenesulfonate / ethanol / 2 h / 50 °C / Inert atmosphere

7.1: 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate / dichloromethane / 0.33 h / 25 °C / Molecular sieve; Inert atmosphere

8.1: hydrogenchloride / water; 1,4-dioxane / 18 h / 120 °C / Inert atmosphere

9.1: formic acid; dihydrogen peroxide / water / 1 h / 0 °C / Inert atmosphere

10.1: potassium permanganate / water; methanol / 1 h / 25 °C / Inert atmosphere

With hydrogenchloride; aluminum (III) chloride; potassium permanganate; n-butyllithium; formic acid; tetrapropylammonium perruthennate; water; dihydrogen peroxide; pyridinium p-toluenesulfonate; pivaloyl chloride; potassium carbonate; hydrazine hydrate; 4-methylmorpholine N-oxide; potassium hydroxide; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; chloroform; water; acetone; toluene;
DOI:10.1021/jm3008689

Reference yield:

: 58393-19-4
2-(tetrahydro-pyran-2-yloxy)-cyclopentanecarboxylic acid ethyl ester

: 625113-52-2
(2R)-2-(3-chloro-4-methanesulfonylphenyl)-3-(2-oxocyclopentyl)propanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 18 h / 0 - 25 °C / Inert atmosphere

2.1: triphenylphosphine; 1H-imidazole; iodine / dichloromethane / 3 h / 0 - 25 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane; n-butyllithium / hexane; tetrahydrofuran / 1 h / -45 - 0 °C / Inert atmosphere

3.2: 3 h / -45 - 0 °C / Inert atmosphere

4.1: pyridinium p-toluenesulfonate / ethanol / 2 h / 50 °C / Inert atmosphere

5.1: 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate / dichloromethane / 0.33 h / 25 °C / Molecular sieve; Inert atmosphere

6.1: hydrogenchloride / water; 1,4-dioxane / 18 h / 120 °C / Inert atmosphere

7.1: formic acid; dihydrogen peroxide / water / 1 h / 0 °C / Inert atmosphere

8.1: potassium permanganate / water; methanol / 1 h / 25 °C / Inert atmosphere

With 1H-imidazole; hydrogenchloride; potassium permanganate; lithium aluminium tetrahydride; n-butyllithium; formic acid; tetrapropylammonium perruthennate; dihydrogen peroxide; iodine; pyridinium p-toluenesulfonate; 4-methylmorpholine N-oxide; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; water;
DOI:10.1021/jm3008689