2-[(2-BROMOBENZYL)OXY]BENZOIC ACID

Base Information

• Chemical Name: 2-[(2-BROMOBENZYL)OXY]BENZOIC ACID
• CAS No.: 743456-83-9
• Molecular Formula: C14H11BrO3
• Molecular Weight: 307.14
• Hs Code.: 2918990090
• Mol file: 743456-83-9.mol

Synonyms:2-[(2-BROMOBENZYL)OXY]BENZOIC ACID;ML-097

Chemical Property of 2-[(2-BROMOBENZYL)OXY]BENZOIC ACID

Chemical Property:

• Boiling Point: 445.4±25.0 °C(Predicted)
• PKA: 3.38±0.36(Predicted)
• PSA: 46.53000
• Density: 1.514±0.06 g/cm3(Predicted)
• LogP: 3.72630
• Solubility.: ≤5mg/ml in DMSO

Purity/Quality:

≥95% ^*data from raw suppliers

ML-097 ≥95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Description: ML-097 is a small molecule pan activator of Ras-related GTPases, activating cell division cycle 42, Ras, and Rac1 with EC50 values of 102, 109, and 151 nM, respectively.

Technology Process of 2-[(2-BROMOBENZYL)OXY]BENZOIC ACID

There total 3 articles about 2-[(2-BROMOBENZYL)OXY]BENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-(2-bromobenzyloxy)benzoic acid methyl ester (329715-27-7) → 2-[(2-bromophenyl)methoxy]benzoic acid (743456-83-9)

Guidance literature:

With potassium hydroxide; In methanol; water; for 2h; Inert atmosphere; Reflux;

DOI:10.1002/chem.201103438

Reference yield:

1-Bromo-2-bromomethyl-benzene (3433-80-5) → 2-[(2-bromophenyl)methoxy]benzoic acid (743456-83-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / Inert atmosphere; Reflux

2: potassium hydroxide / methanol; water / 2 h / Inert atmosphere; Reflux

With potassium carbonate; potassium hydroxide; In methanol; water; acetone;

DOI:10.1002/chem.201103438

Reference yield:

methyl salicylate (119-36-8,8024-54-2) → 2-[(2-bromophenyl)methoxy]benzoic acid (743456-83-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / Inert atmosphere; Reflux

2: potassium hydroxide / methanol; water / 2 h / Inert atmosphere; Reflux

With potassium carbonate; potassium hydroxide; In methanol; water; acetone;

DOI:10.1002/chem.201103438

upstream raw materials:

2-(2-bromobenzyloxy)benzoic acid methyl ester

1-Bromo-2-bromomethyl-benzene

methyl salicylate