YS121

Base Information

Chemical Name:YS121
CAS No.:916482-17-2
Molecular Formula:C20H26ClN3O2S
Molecular Weight:407.964
Hs Code.:
Mol file:916482-17-2.mol

Synonyms:YS121

Suppliers and Price of YS121

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Cayman Chemical
YS-121 ≥98%
25mg
$ 814.00

Cayman Chemical
YS-121 ≥98%
5mg
$ 210.00

Cayman Chemical
YS-121 ≥98%
1mg
$ 48.00

Cayman Chemical
YS-121 ≥98%
10mg
$ 373.00

ApexBio Technology
YS-121
5mg (solution)
$ 269.00

AK Scientific
2-[4-Chloro-6-(2,3-dimethylanilino)pyrimidin-2-yl]sulfanyloctanoicacid
10mg
$ 564.00

Total 20 raw suppliers

Chemical Property of YS121

Chemical Property:

PSA：100.41000
LogP:6.07910
Solubility.:≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide

Purity/Quality:

≥98% ^*data from raw suppliers

YS-121 ≥98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description Microsomal prostaglandin E2 synthase-1 (mPGES-1), with cyclooxygenase-2 (COX-2), synthesizes PGE2, which is directly involved in signaling during inflammation, fever, and pain. 5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs), which are pro-inflammatory mediators. YS-121 is a dual inhibitor of mPGES-1 (IC50 = 3.9 μM) and 5-LO (IC50 = 4.1 μM). It effectively inhibits PGE2 and LT synthesis in both cell free and intact cell assays. Moreover, YS-121 (1.5 mg/kg, intraperitoneal) reduced pleural levels of PGE2 and LTB4 while blocking exudate formation and leukocyte infiltration in carrageenan-induced rat pleurisy. YS-121 has minor effects on COX-1 and COX-2, inhibiting these enzymes 24.8% and 38%, respectively, at 10 μM.

Technology Process of YS121

There total 1 articles about YS121 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: