[4-(1-Methoxyethoxy)-3-methylpyridin-2-yl]methanol

Base Information

• Chemical Name: [4-(1-Methoxyethoxy)-3-methylpyridin-2-yl]methanol
• CAS No.: 206990-53-6
• Molecular Formula: C₁₀H₁₅NO₃
• Molecular Weight: 197.234
• Hs Code.: 2933399990
• DSSTox Substance ID: DTXSID40703381
• Mol file: 206990-53-6.mol

Synonyms:DTXSID40703381;[4-(1-methoxyethoxy)-3-methylpyridin-2-yl]methanol

Chemical Property of [4-(1-Methoxyethoxy)-3-methylpyridin-2-yl]methanol

Chemical Property:

• PSA: 51.58000
• LogP: 1.25350
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 197.10519334
• Heavy Atom Count: 14
• Complexity: 165

Purity/Quality:

99% ^*data from raw suppliers

2-HYDROXYMETHYL-4-METHOXYETHOXY-3-METHYLPYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=CN=C1CO)OC(C)OC

Technology Process of [4-(1-Methoxyethoxy)-3-methylpyridin-2-yl]methanol

There total 3 articles about [4-(1-Methoxyethoxy)-3-methylpyridin-2-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

Acetic acid 4-(2-methoxy-ethoxy)-3-methyl-pyridin-2-ylmethyl ester (206990-60-5) → [4-(2-Methoxy-ethoxy)-3-methyl-pyridin-2-yl]-methanol (206990-53-6)

Guidance literature:

With sodium hydroxide; In methanol; Heating;

DOI:10.1021/jm970165r

Reference yield:

2,3-dimethyl-4-nitropyridine N-oxide (37699-43-7) → [4-(2-Methoxy-ethoxy)-3-methyl-pyridin-2-yl]-methanol (206990-53-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 53 percent / K₂CO₃ / 20 h / Heating

2: 94 percent / 110 °C

3: 63 percent / aq. NaOH / methanol / Heating

With sodium hydroxide; potassium carbonate; In methanol;

DOI:10.1021/jm970165r

Reference yield:

4-(2-Methoxy-ethoxy)-2,3-dimethyl-pyridine 1-oxide (206990-48-9) → [4-(2-Methoxy-ethoxy)-3-methyl-pyridin-2-yl]-methanol (206990-53-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / 110 °C

2: 63 percent / aq. NaOH / methanol / Heating

With sodium hydroxide; In methanol;

DOI:10.1021/jm970165r

upstream raw materials:

Acetic acid 4-(2-methoxy-ethoxy)-3-methyl-pyridin-2-ylmethyl ester

2,3-dimethyl-4-nitropyridine N-oxide

4-(2-Methoxy-ethoxy)-2,3-dimethyl-pyridine 1-oxide