SHP099

Base Information

• Chemical Name: SHP099
• CAS No.: 1801747-42-1
• Molecular Formula: C₁₆H₁₉Cl₂N₅
• Molecular Weight: 352.266
• Mol file: 1801747-42-1.mol

Synonyms:SHP099;6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine;SHP-099 (free base)

Chemical Property of SHP099

Chemical Property:

• Boiling Point: 530.4±50.0 °C(Predicted)
• PKA: 9.05±0.20(Predicted)
• PSA: 81.06000
• Density: 1.326±0.06 g/cm3(Predicted)
• LogP: 4.69670

Purity/Quality:

97% ^*data from raw suppliers

SHP099freebase >99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of SHP099

There total 1 articles about SHP099 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine (212779-33-4) → 6-(4-amino-4-methylpiperidine-1-yl)-3-(2,3-dichlorophenyl)pyrazine-2-amine (1801747-42-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium phosphate / 1-methyl-pyrrolidin-2-one / 36 h / 140 °C

2: hydrogenchloride / 1,4-dioxane / 2 h / 140 °C

With hydrogenchloride; potassium phosphate; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one;

DOI:10.1021/acs.jmedchem.6b00680

upstream raw materials:

6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine