3-BROMOMETHYL-PHTHALIC ACID DIMETHYL ESTER

Base Information

• Chemical Name: 3-BROMOMETHYL-PHTHALIC ACID DIMETHYL ESTER
• CAS No.: 24129-04-2
• Molecular Formula: C11H11BrO4
• Molecular Weight: 287.11
• Hs Code.: 2917399090
• Mol file: 24129-04-2.mol

Synonyms:3-BROMOMETHYL-PHTHALIC ACID DIMETHYL ESTER;1,2-Benzenedicarboxylic acid, 3-(broMoMethyl)-, 1,2-diMethyl ester;Dimethyl 3-(bromomethyl)phthalate

Chemical Property of 3-BROMOMETHYL-PHTHALIC ACID DIMETHYL ESTER

Chemical Property:

• PSA: 52.60000
• LogP: 2.15470

Purity/Quality:

97% ^*data from raw suppliers

3-Bromomethyl-phthalicaciddimethylester 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMOMETHYL-PHTHALIC ACID DIMETHYL ESTER

There total 4 articles about 3-BROMOMETHYL-PHTHALIC ACID DIMETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

dimethyl 3-methylbenzene-1,2-dicarboxylate (21483-46-5) → 3-bromomethylphthalate dimethyl ester (24129-04-2)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; at 70 ℃; 200W light;

Reference yield:

3-methylphthalic acid (37102-74-2) → 3-bromomethylphthalate dimethyl ester (24129-04-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 8 h / 80 °C / Microwave irradiation

2: N-Bromosuccinimide / dichloromethane / 3 h

With N-Bromosuccinimide; sulfuric acid; In dichloromethane;

DOI:10.1016/j.bmc.2015.09.017

Reference yield:

→ 3-bromomethylphthalate dimethyl ester (24129-04-2)

Guidance literature:

3-Methyl-Verb., N-Brom-succinimid /CCl4 bei GGw. v. etwas Azo-bis-isobutyronitril (ca. 2h);

upstream raw materials:

phthalic acid dimethyl ester

(E)-3,3'-(diazene-1,2-diyl)bis(2-methylpropanenitrile)

dimethyl 3-methylbenzene-1,2-dicarboxylate

3-methylphthalic acid

Downstream raw materials:

3-azidomethyl-phthalic acid dimethyl ester

3-[(t-butoxycarbonyl-methyl-amino)-methyl]-phthalic dimethyl ester

Refernces

• 1、 Thangavelu, Bharani,Mutthamsetty, Vinay,Wang, Qinzhe,Viola, Ronald E.. "Design and optimization of aspartate N-acetyltransferase inhibitors for the potential treatment of Canavan disease". supporting information. p. 870 - 885. Retrieved 2017/02/05.
• 2、 Thangavelu, Bharani,Bhansali, Pravin,Viola, Ronald E.. "Elaboration of a fragment library hit produces potent and selective aspartate semialdehyde dehydrogenase inhibitors". . p. 6622 - 6631. Retrieved 2015/10/19.