1'-Benzyl-2H-spiro[benzofuran-3,4'-piperidine]

Base Information

Chemical Name:1'-Benzyl-2H-spiro[benzofuran-3,4'-piperidine]
CAS No.:72374-35-7
Molecular Formula:C19H21NO
Molecular Weight:279.382
Hs Code.:2934999090
DSSTox Substance ID:DTXSID40502871
Nikkaji Number:J3.016.327C
Wikidata:Q82356250
Mol file:72374-35-7.mol

Synonyms:1'-Benzyl-2H-spiro[benzofuran-3,4'-piperidine];72374-35-7;1'-benzyl-spiro[benzofuran-3,4'-piperidine];1'-benzylspiro[2H-1-benzofuran-3,4'-piperidine];SCHEMBL1587952;DTXSID40502871;BS-49837;CS-0199218;E76228;1'-Benzyl-2H-spiro[1-benzofuran-3,4'-piperidine]

Suppliers and Price of 1'-Benzyl-2H-spiro[benzofuran-3,4'-piperidine]

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
1'-BENZYL-2H-SPIRO[BENZOFURAN-3,4'-PIPERIDINE] 95.00%
5MG
$ 495.77

1Pluschem
95+%
250mg
$ 48.00

Total 5 raw suppliers

Chemical Property of 1'-Benzyl-2H-spiro[benzofuran-3,4'-piperidine]

Chemical Property:

PSA：12.47000
LogP:3.55070
XLogP3:3.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:279.162314293
Heavy Atom Count:21
Complexity:342

Purity/Quality:

99% ^*data from raw suppliers

1'-BENZYL-2H-SPIRO[BENZOFURAN-3,4'-PIPERIDINE] 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC12COC3=CC=CC=C23)CC4=CC=CC=C4

Technology Process of 1'-Benzyl-2H-spiro[benzofuran-3,4'-piperidine]

There total 8 articles about 1'-Benzyl-2H-spiro[benzofuran-3,4'-piperidine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 909034-78-2
1-benzyl-4-[(2-bromophenoxy)methyl]-1,2,3,6-tetrahydropyridine

: 72374-35-7
1'-benzylspiro[benzofuran-2(3H),4'-piperidine]

Guidance literature:: 1-benzyl-4-[(2-bromophenoxy)methyl]-1,2,3,6-tetrahydropyridine; With tri-n-butyl-tin hydride; In toluene; Heating / reflux;

With 2,2'-azobis(isobutyronitrile); In toluene; for 3h; Heating / reflux;

With potassium fluoride; In diethyl ether; water; at 20 - 50 ℃; for 18h;

Reference yield:

: 72374-32-4
2-(1-benzyl-4-hydroxymethyl-piperidin-4-yl)-phenol

: 72374-35-7
1'-benzylspiro[benzofuran-2(3H),4'-piperidine]

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; at 190 ℃; for 8h;
DOI:10.1016/0040-4020(79)80090-3

Reference yield:

: 586-95-8
pyridine-4-methanol

: 72374-35-7
1'-benzylspiro[benzofuran-2(3H),4'-piperidine]

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 8 h / 20 °C

2: dichloromethane / 24 h / 20 °C

3: sodium tetrahydroborate / methanol / 2 h / 0 - 20 °C

4: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 20 h / 95 °C

With sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; triphenylphosphine; diethylazodicarboxylate; In methanol; dichloromethane; toluene; 1: Mitsunobu reaction;
DOI:10.1002/jhet.630