Thiophene-3-ol, tetrahydro-4-(2-hydroxyethylidene)-, (3R)- (9CI)

Base Information

Chemical Name:Thiophene-3-ol, tetrahydro-4-(2-hydroxyethylidene)-, (3R)- (9CI)
CAS No.:688797-31-1
Molecular Formula:C6H10O2S
Molecular Weight:146.2074
Hs Code.:
Mol file:688797-31-1.mol

Synonyms:Thiophene-3-ol, tetrahydro-4-(2-hydroxyethylidene)-, (3R)- (9CI)

Suppliers and Price of Thiophene-3-ol, tetrahydro-4-(2-hydroxyethylidene)-, (3R)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Thiophene-3-ol, tetrahydro-4-(2-hydroxyethylidene)-, (3R)- (9CI)

Chemical Property:

PSA：65.76000
LogP:0.01280

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Thiophene-3-ol, tetrahydro-4-(2-hydroxyethylidene)-, (3R)- (9CI)

There total 5 articles about Thiophene-3-ol, tetrahydro-4-(2-hydroxyethylidene)-, (3R)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 688797-21-9
(R)-3-benzyloxy-4-(2-benzyloxyethylidene)tetrahydrothiophene

: 688797-31-1
(R)-4-(2-hydroxyethylidene)tetrahydrothiophen-3-ol

Guidance literature:: With boron trichloride; In dichloromethane; at -78 ℃; for 3h;
DOI:10.1021/jo035735b

Reference yield:

: methyl 2,5-di-O-benzyl-3-deoxy-3-methylene-D-erythro-pentofuranoside

: 688797-31-1
(R)-4-(2-hydroxyethylidene)tetrahydrothiophen-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / aqueous HCl / dioxane / 24 h / 20 °C

2: 91 percent / lithium borohydride / tetrahydrofuran / 24 h / 20 °C

3: 70 percent / pyridine / CH₂Cl₂ / 3 h / 20 °C

4: 17 percent / sodium sulfide / dimethylformamide / 4 h / 0 °C

5: 69 percent / boron trichloride / CH₂Cl₂ / 3 h / -78 °C

With pyridine; hydrogenchloride; sodium sulfide; lithium borohydride; boron trichloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo035735b

Reference yield:

: 2,5-di-O-benzyl-3-deoxy-3-methylene-D-erythro-pentofuranose

: 688797-31-1
(R)-4-(2-hydroxyethylidene)tetrahydrothiophen-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / lithium borohydride / tetrahydrofuran / 24 h / 20 °C

2: 70 percent / pyridine / CH₂Cl₂ / 3 h / 20 °C

3: 17 percent / sodium sulfide / dimethylformamide / 4 h / 0 °C

4: 69 percent / boron trichloride / CH₂Cl₂ / 3 h / -78 °C

With pyridine; sodium sulfide; lithium borohydride; boron trichloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo035735b