2-Pyridinylboronic acid MIDA ester

Base Information

• Chemical Name: 2-Pyridinylboronic acid MIDA ester
• CAS No.: 1104637-58-2
• Molecular Formula: C10H11BN2O4
• Molecular Weight: 234.019
• Mol file: 1104637-58-2.mol

Synonyms:2-Pyridinylboronic acid MIDA ester;2-Pyridylboronic acid MIDA ester;2-Pyridinylboronic acid methyliminodiacetic acid ester;Pyridine-2-boronic acid MIDA ester

Chemical Property of 2-Pyridinylboronic acid MIDA ester

Chemical Property:

• PSA: 77.85000
• LogP: -1.25350
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-PyridinylboronicAcidMIDAEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Pyridinylboronic Acid MIDA Ester can be used for HIV replication inhibitors.

Technology Process of 2-Pyridinylboronic acid MIDA ester

There total 3 articles about 2-Pyridinylboronic acid MIDA ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

lithium (pyridine-2-yl)triisopropoxyborate + N-methyliminodiacetic acid (4408-64-4) → 6-methyl-2-(pyridin-2-yl)-1,3,6,2-dioxazaborocane-4,8-dione (1104637-58-2)

Guidance literature:

In tetrahydrofuran; hexane; dimethyl sulfoxide; at 110 - 120 ℃; Inert atmosphere;

Reference yield: 27.0%

2-bromo-pyridine (109-04-6) + N-methyliminodiacetic acid (4408-64-4) → 6-methyl-2-(pyridin-2-yl)-1,3,6,2-dioxazaborocane-4,8-dione (1104637-58-2)

Guidance literature:

2-bromo-pyridine; With n-butyllithium; Triisopropyl borate; In tetrahydrofuran; hexane; at -78 - 20 ℃;

N-methyliminodiacetic acid; In tetrahydrofuran; hexane; dimethyl sulfoxide; at 75 ℃; for 2h; under 1 Torr;

Reference yield:

2-bromo-pyridine (109-04-6) → 6-methyl-2-(pyridin-2-yl)-1,3,6,2-dioxazaborocane-4,8-dione (1104637-58-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / -78 °C / Inert atmosphere

1.2: -78 - 23 °C

2.1: hexane; dimethyl sulfoxide; tetrahydrofuran / 110 - 120 °C / Inert atmosphere

In tetrahydrofuran; hexane; dimethyl sulfoxide;

upstream raw materials:

2-bromo-pyridine

N-methyliminodiacetic acid

Downstream raw materials:

4-(pyridine-2-yl)benzonitrile

1-(4-(pyridin-2-yl)phenyl)ethanone

2-(4-methylphenyl)pyridine

2-(2-methylphenyl)pyridine

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