5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine

Base Information

• Chemical Name: 5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine
• CAS No.: 493028-20-9
• Molecular Formula: C12H14N2OS
• Molecular Weight: 234.32
• Hs Code.: 2934100090
• DSSTox Substance ID: DTXSID10356681
• Wikidata: Q82136197
• ChEMBL ID: CHEMBL1872207
• Mol file: 493028-20-9.mol

Synonyms:493028-20-9;5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine;5-ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine;CBFbeta Inhibitor;5-Ethyl-4-(4-methoxyphenyl)thiazol-2-yl-amine;CBF Inhibitor;CBF? Inhibitor;CBF beta;CBF(c)micro Inhibitor;thiazol-2-amine, 17;Oprea1_378728;Oprea1_717807;RUNX1-IN-17;CHEMBL1872207;SCHEMBL20767251;BDBM31185;DTXSID10356681;MFCD02232182;AKOS000300270;NCGC00182728-01;NS-03123;CS-0084454;EN300-69596;5-Ethyl-4-(4'-methoxyphenyl)-thiazolyl-2-amine;SR-01000313753;SR-01000313753-1;Z57326240

Chemical Property of 5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine

Chemical Property:

• PSA: 76.38000
• LogP: 3.54450
• Storage Temp.: +2C to +8C
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 234.08268425
• Heavy Atom Count: 16
• Complexity: 219

Purity/Quality:

99% ^*data from raw suppliers

5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1=C(N=C(S1)N)C2=CC=C(C=C2)OC
• Description: Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.
• Uses: Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.