(S)-2-(1-aMinoethyl)-4-chlorophenol

Base Information

• Chemical Name: (S)-2-(1-aMinoethyl)-4-chlorophenol
• CAS No.: 1228569-39-8
• Molecular Formula: C8H10ClNO
• Molecular Weight: 171.6241
• Mol file: 1228569-39-8.mol

Synonyms:(S)-2-(1-aMinoethyl)-4-chlorophenol;2-((1S)-1-AMINOETHYL)-4-CHLOROPHENOL

Chemical Property of (S)-2-(1-aMinoethyl)-4-chlorophenol

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Boiling Point: 298.549°C at 760 mmHg
• PKA: 8.82±0.48(Predicted)
• Flash Point: 162.566°C
• PSA: 46.25000
• Density: 1.601g/cm³
• LogP: 2.76560

Purity/Quality:

99% ^*data from raw suppliers

(S)-2-(1-Aminoethyl)-4-chlorophenol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(1-aMinoethyl)-4-chlorophenol

There total 3 articles about (S)-2-(1-aMinoethyl)-4-chlorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.9%

C8H10ClNO (74302-66-2) → (S)-2-(1-aminoethyl)-4-chlorophenol (1228569-39-8)

Guidance literature:

With L-Tartaric acid; In tetrahydrofuran; water; at 20 - 50 ℃; for 8h; Inert atmosphere;

DOI:10.1002/anie.201301676

Reference yield:

5'-chloro-2'-hydroxyacetophenone imine (1019187-32-6) → (S)-2-(1-aminoethyl)-4-chlorophenol (1228569-39-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: titanium(IV) isopropylate / tetrahydrofuran / 0.5 h / 15 °C / Inert atmosphere

1.2: 0.83 h / Inert atmosphere

2.1: L-Tartaric acid / tetrahydrofuran; water / 8 h / 20 - 50 °C / Inert atmosphere

With titanium(IV) isopropylate; L-Tartaric acid; In tetrahydrofuran; water;

DOI:10.1002/anie.201301676

Reference yield:

5-chloro-2-hydroxyacetophenone (1450-74-4) → (S)-2-(1-aminoethyl)-4-chlorophenol (1228569-39-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ammonia / Isopropyl acetate; methanol / 18 h / 5 - 20 °C / Inert atmosphere

2.1: titanium(IV) isopropylate / tetrahydrofuran / 0.5 h / 15 °C / Inert atmosphere

2.2: 0.83 h / Inert atmosphere

3.1: L-Tartaric acid / tetrahydrofuran; water / 8 h / 20 - 50 °C / Inert atmosphere

With titanium(IV) isopropylate; L-Tartaric acid; ammonia; In tetrahydrofuran; methanol; Isopropyl acetate; water;

DOI:10.1002/anie.201301676

upstream raw materials:

5-chloro-2-hydroxyacetophenone

5'-chloro-2'-hydroxyacetophenone imine

C₈H₁₀ClNO

Refernces