ethyl 4-(acetyloxy)-5,7-dimethoxynaphthalene-2-carboxylate

Base Information

• Chemical Name: ethyl 4-(acetyloxy)-5,7-dimethoxynaphthalene-2-carboxylate
• CAS No.: 155816-92-5
• Molecular Formula: C₁₇H₁₈O₆
• Molecular Weight: 318.326
• Mol file: 155816-92-5.mol

Synonyms:2-Naphthalenecarboxylic acid, 4-(acetyloxy)-5,7-diMethoxy-, ethyl ester

Chemical Property of ethyl 4-(acetyloxy)-5,7-dimethoxynaphthalene-2-carboxylate

Chemical Property:

• Vapor Pressure: 3.3E-09mmHg at 25°C
• Boiling Point: 475.5°C at 760 mmHg
• Flash Point: 210.6°C
• PSA: 71.06000
• Density: 1.207g/cm³
• LogP: 2.95900

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 4-(acetyloxy)-5,7-dimethoxynaphthalene-2-carboxylate

There total 3 articles about ethyl 4-(acetyloxy)-5,7-dimethoxynaphthalene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(E)-4-(3,5-dimethoxyphenyl)-3-(ethoxycarbonyl)but-3-enoic acid (607356-91-2) + acetic anhydride (108-24-7) → ethyl 4-acetoxy-5,7-dimethoxy-2-naphthoate (155816-92-5)

Guidance literature:

With sodium acetate; at 160 ℃; for 0.166667h;

DOI:10.1055/s-0031-1290429

Reference yield:

3,5-dimethoxybenzaldehdye (7311-34-4) → ethyl 4-acetoxy-5,7-dimethoxy-2-naphthoate (155816-92-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran / 3 h / 0 °C

2: trifluoroacetic acid / dichloromethane / 10 h

3: sodium acetate / 0.17 h / 160 °C

With sodium acetate; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; 1: Horner-Wadsworth-Emmons reaction;

DOI:10.1055/s-0031-1290429

Reference yield:

C19H26O6 → ethyl 4-acetoxy-5,7-dimethoxy-2-naphthoate (155816-92-5)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 10 h

2: sodium acetate / 0.17 h / 160 °C

With sodium acetate; trifluoroacetic acid; In dichloromethane;

DOI:10.1055/s-0031-1290429

upstream raw materials:

(E)-4-(3,5-dimethoxyphenyl)-3-(ethoxycarbonyl)but-3-enoic acid

acetic anhydride

3,5-dimethoxybenzaldehdye