5-Amino-1,3-dimethyl-6-piperidin-1-yl-1,3-dihydro-benzoimidazol-2-one

Base Information

Chemical Name:5-Amino-1,3-dimethyl-6-piperidin-1-yl-1,3-dihydro-benzoimidazol-2-one
CAS No.:878432-74-7
Molecular Formula:C14H20N4O
Molecular Weight:260.33
Hs Code.:2933990090
European Community (EC) Number:855-050-3
ChEMBL ID:CHEMBL2335382
Mol file:878432-74-7.mol

Synonyms:5-Amino-1,3-dimethyl-6-piperidin-1-yl-1,3-dihydro-benzoimidazol-2-one;878432-74-7;5-amino-1,3-dimethyl-6-piperidin-1-ylbenzimidazol-2-one;5-Amino-1,3-dimethyl-6-(piperidin-1-yl)-1H-benzo[d]imidazol-2(3H)-one;5-amino-1,3-dimethyl-6-(piperidin-1-yl)-2,3-dihydro-1H-1,3-benzodiazol-2-one;CHEMBL2335382;STK784420;AKOS000297445;CS-0238882;EN300-201615;Z1993521613;5-amino-1,3-dimethyl-6-(piperidin-1-yl)-1,3-dihydro-2H-benzimidazol-2-one

Suppliers and Price of 5-Amino-1,3-dimethyl-6-piperidin-1-yl-1,3-dihydro-benzoimidazol-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
5-Amino-1,3-dimethyl-6-piperidin-1-yl-1,3-dihydro-benzoimidazol-2-one
1g
$ 378.00

Crysdot
5-Amino-1,3-dimethyl-6-(piperidin-1-yl)-1H-benzo[d]imidazol-2(3H)-one 97%
5g
$ 874.00

American Custom Chemicals Corporation
5-AMINO-1,3-DIMETHYL-6-PIPERIDIN-1-YL-1,3-DIHYDRO-BENZOIMIDAZOL-2-ONE 95.00%
500MG
$ 777.32

AK Scientific
5-Amino-1,3-dimethyl-6-piperidin-1-yl-1,3-dihydro-benzoimidazol-2-one
1g
$ 560.00

Total 3 raw suppliers

Chemical Property of 5-Amino-1,3-dimethyl-6-piperidin-1-yl-1,3-dihydro-benzoimidazol-2-one

Chemical Property:

PSA：56.19000
LogP:2.09570
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:260.16371127
Heavy Atom Count:19
Complexity:355

Purity/Quality:

98%min ^*data from raw suppliers

5-Amino-1,3-dimethyl-6-piperidin-1-yl-1,3-dihydro-benzoimidazol-2-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C2=C(C=C(C(=C2)N)N3CCCCC3)N(C1=O)C

Technology Process of 5-Amino-1,3-dimethyl-6-piperidin-1-yl-1,3-dihydro-benzoimidazol-2-one

There total 3 articles about 5-Amino-1,3-dimethyl-6-piperidin-1-yl-1,3-dihydro-benzoimidazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1,3-dimethyl-5-nitro-6-(piperidin-1-yl)-1H-benzo[d]imidazol-2(3H)-one

: 878432-74-7
5-amino-1,3-dimethyl-6-(piperidin-1-yl)-1H-benzo[d]imidazole-2(3H)-one

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 16h; under 760.051 Torr;
DOI:10.1021/ml5002932 DOI:10.1021/acsmedchemlett.6b00092

Reference yield:

: 5-fluoro-1,3-dimethyl-1,3-dihydro-2H-benzimidazol-2-one

: 878432-74-7
5-amino-1,3-dimethyl-6-(piperidin-1-yl)-1H-benzo[d]imidazole-2(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: acetic anhydride; nitric acid / 1 h / -30 - 0 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

3: palladium 10% on activated carbon; hydrogen / ethanol / 16 h / 20 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; nitric acid; acetic anhydride; N-ethyl-N,N-diisopropylamine; In ethanol; dimethyl sulfoxide;
DOI:10.1021/ml5002932

Reference yield:

: 5-fluoro-1,3-dimethyl-6-nitro-1,3-dihydro-2H-benzimidazol-2-one

: 878432-74-7
5-amino-1,3-dimethyl-6-(piperidin-1-yl)-1H-benzo[d]imidazole-2(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 1 h / 120 °C / Inert atmosphere; Microwave irradiation

2: palladium 10% on activated carbon; hydrogen / ethanol / 16 h / 20 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In ethanol; dimethyl sulfoxide;
DOI:10.1021/ml5002932