2-chloro-1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanone

Base Information

Chemical Name:2-chloro-1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanone
CAS No.:943126-72-5
Molecular Formula:C11H10ClFO2
Molecular Weight:228.651
Hs Code.:
European Community (EC) Number:619-008-6
DSSTox Substance ID:DTXSID101178798
Mol file:943126-72-5.mol

Synonyms:943126-72-5;2-chloro-1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanone;2-chloro-1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-ethanone;Ethanone, 2-chloro-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-;SCHEMBL908011;JOIVVMUMDLHKRF-UHFFFAOYSA-N;DTXSID101178798;2-Chloro-1-(6-fluorochroman-2-yl)ethan-1-one;2-Chloro-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)ethanone

Suppliers and Price of 2-chloro-1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 9 raw suppliers

Chemical Property of 2-chloro-1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanone

Chemical Property:

PSA：26.30000
LogP:2.32720
XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:228.0353354
Heavy Atom Count:15
Complexity:247

Purity/Quality:: 99.0% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2=C(C=CC(=C2)F)OC1C(=O)CCl

Technology Process of 2-chloro-1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanone

There total 15 articles about 2-chloro-1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 99199-61-8
6-fluoro-3,4-dihydro-2H-benzopyran-2-carboxylic acid ethyl ester

: 593-71-5
Chloroiodomethane

: 943126-72-5
2-chloro-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)ethan-1-one

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -60 ℃; for 3h; Inert atmosphere;

Reference yield: 89.0%

: 99199-61-8
6-fluoro-3,4-dihydro-2H-benzopyran-2-carboxylic acid ethyl ester

: 74-97-5
chlorobromomethane

: 943126-72-5
2-chloro-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)ethan-1-one

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -50 ℃; for 3h; Inert atmosphere;

Reference yield: 89.0%

: 593-71-5
Chloroiodomethane

: 6-fluoro-2-cyano-3,4-dihydro-2H-1-benzopyran

: 943126-72-5
2-chloro-1-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)ethan-1-one

Guidance literature:: Chloroiodomethane; With zinc; In tetrahydrofuran; at 65 ℃; for 2h;

6-fluoro-2-cyano-3,4-dihydro-2H-1-benzopyran; In tetrahydrofuran; at 0 - 25 ℃; for 20h;

With water; ammonium chloride; In tetrahydrofuran; at 25 ℃; for 25h;