N-(5-IODO-PYRIDIN-2-YL)-4-METHYL-BENZENESULFONAMIDE

Base Information

• Chemical Name: N-(5-IODO-PYRIDIN-2-YL)-4-METHYL-BENZENESULFONAMIDE
• CAS No.: 209971-43-7
• Molecular Formula: C12H11IN2O2S
• Molecular Weight: 374.202
• Mol file: 209971-43-7.mol

Synonyms:N-(5-IODO-PYRIDIN-2-YL)-4-METHYL-BENZENESULFONAMIDE;N-(5-iodo-2-pyridinyl)-4-methylBenzenesulfonamide

Chemical Property of N-(5-IODO-PYRIDIN-2-YL)-4-METHYL-BENZENESULFONAMIDE

Chemical Property:

• PSA: 67.44000
• LogP: 3.94920

Purity/Quality:

≥95% ^*data from raw suppliers

N-(5-Iodo-pyridin-2-yl)-4-methyl-benzenesulfonamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(5-IODO-PYRIDIN-2-YL)-4-METHYL-BENZENESULFONAMIDE

There total 3 articles about N-(5-IODO-PYRIDIN-2-YL)-4-METHYL-BENZENESULFONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-amino-5-iodopyridine (20511-12-0) + p-toluenesulfonyl chloride (98-59-9) → N-(5-iodopyridin-2-yl)-4-methylbenzenesulfonamide (209971-43-7)

Guidance literature:

With pyridine; at 20 ℃; for 16h;

DOI:10.1016/j.bmcl.2011.07.117

Reference yield: 85.0%

2-amino-5-iodopyridine (20511-12-0) + p-toluenesulfonyl chloride (98-59-9) → N-(5-iodopyridin-2-yl)-4-methylbenzenesulfonamide (209971-43-7)

Guidance literature:

With pyridine; at 80 - 90 ℃;

DOI:10.1055/s-1998-2078

Reference yield:

2-aminopyridine (504-29-0) → N-(5-iodopyridin-2-yl)-4-methylbenzenesulfonamide (209971-43-7)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; periodic acid / sulfuric acid; water; acetic acid / 2 h / 80 °C

2: pyridine / 18 h / 90 °C

With iodine; periodic acid; In pyridine; sulfuric acid; water; acetic acid;

upstream raw materials:

2-amino-5-iodopyridine

p-toluenesulfonyl chloride

2-aminopyridine

Downstream raw materials:

2-[5-iodo-2-{[(4-methylphenyl)sulfonyl]imino}pyridin-1(2H)-yl]acetamide

2,2,2-trifluoro-N-(6-iodoimidazo[1,2-a]pyridin-2-yl)acetamide

N-[3-(4-Chloro-phenylsulfanyl)-6-iodo-imidazo[1,2-a]pyridin-2-yl]-2,2,2-trifluoro-acetamide

N-(5-iodo-1-(3-oxopentan-2-yl)pyridin-2(1H)-ylidene)-4-methylbenzenesulfonamide

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