N-(2-Hydroxy-5-((1S)-1-hydroxy-2-(((1R)-2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)phenyl)formamide

Base Information

Chemical Name:N-(2-Hydroxy-5-((1S)-1-hydroxy-2-(((1R)-2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)phenyl)formamide
CAS No.:67346-50-3
Molecular Formula:C19H24N2O4
Molecular Weight:344.4
Hs Code.:
UNII:ZP145530CI
DSSTox Substance ID:DTXSID90217701
Nikkaji Number:J817.047I
Wikidata:Q27295830
Mol file:67346-50-3.mol

Synonyms:67346-50-3;UNII-ZP145530CI;N-(2-Hydroxy-5-((1S)-1-hydroxy-2-(((1R)-2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)phenyl)formamide;ZP145530CI;Formoterol Fumarate Dihydrate EP Impurity I (S,R-isomer);N-[2-hydroxy-5-[(1S)-1-hydroxy-2-[[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]phenyl]formamide;(S,R) formoterol;(S,R)-Formoterol;SCHEMBL117865;DTXSID90217701;BPZSYCZIITTYBL-BFUOFWGJSA-N;Q27295830;FORMAMIDE, N-(2-HYDROXY-5-((1S)-1-HYDROXY-2-(((1R)-2-(4-METHOXYPHENYL)-1-METHYLETHYL)AMINO)ETHYL)PHENYL)-

Suppliers and Price of N-(2-Hydroxy-5-((1S)-1-hydroxy-2-(((1R)-2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)phenyl)formamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of N-(2-Hydroxy-5-((1S)-1-hydroxy-2-(((1R)-2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)phenyl)formamide

Chemical Property:

Boiling Point:603.2±55.0 °C(Predicted)
PKA:8.95±0.50(Predicted)
PSA：94.31000
Density:1.233±0.06 g/cm3(Predicted)
LogP:3.26370
XLogP3:1.8
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:344.17360725
Heavy Atom Count:25
Complexity:388

Purity/Quality:: > 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CC1=CC=C(C=C1)OC)NCC(C2=CC(=C(C=C2)O)NC=O)O
Isomeric SMILES:C[C@H](CC1=CC=C(C=C1)OC)NC[C@H](C2=CC(=C(C=C2)O)NC=O)O
Uses (1S,2R)-Formoterol-Formoterol is used as an antiasthmatic. (1S,2R)-Formoterol targets the adrenergic receptors.

Technology Process of N-(2-Hydroxy-5-((1S)-1-hydroxy-2-(((1R)-2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)phenyl)formamide

There total 9 articles about N-(2-Hydroxy-5-((1S)-1-hydroxy-2-(((1R)-2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)phenyl)formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-[5-((S)-2-{Benzyl-[(R)-2-(4-methoxy-phenyl)-1-methyl-ethyl]-amino}-1-hydroxy-ethyl)-2-benzyloxy-phenyl]-formamide

: 67346-50-3,67346-49-0
(S,R)-Formoterol

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1016/S0040-4039(97)00088-9

Reference yield:

: 122-84-9
4-methoxybenzyl methyl ketone

: 67346-50-3,67346-49-0
(S,R)-Formoterol

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pt-C / ethanol

2: 90 °C

3: H₂ / PtO₂

5: H₂ / Pd-C / ethanol

With hydrogen; platinum(IV) oxide; palladium on activated charcoal; platinum on activated charcoal; In ethanol;
DOI:10.1016/S0040-4039(97)00088-9

Reference yield:

: 43229-01-2
4-benzyloxy-3-nitrophenacyl bromide

: 67346-50-3,67346-49-0
(S,R)-Formoterol

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / oxazaborolidine from cis (1S,2R)-aminoindanol and trimethylboroxine, BH₃ / tetrahydrofuran / -15 °C

2: 98 percent / aqueous sodium hydroxide / methanol / 0.5 h

3: 90 °C

4: H₂ / PtO₂

6: H₂ / Pd-C / ethanol

With sodium hydroxide; oxazaborolidine from cis (1S,2R)-aminoindanol and trimethylboroxine; borane; hydrogen; platinum(IV) oxide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol;
DOI:10.1016/S0040-4039(97)00088-9