2-Ethyl-6-Methylisonicotinonitrile

Base Information

• Chemical Name: 2-Ethyl-6-Methylisonicotinonitrile
• CAS No.: 945463-94-5
• Molecular Formula: C₉H₁₀N₂
• Molecular Weight: 146.192
• Hs Code.: 2933399090
• Mol file: 945463-94-5.mol

Synonyms:2-Ethyl-6-Methylisonicotinonitrile

Chemical Property of 2-Ethyl-6-Methylisonicotinonitrile

Chemical Property:

• Boiling Point: 228.0±35.0 °C(Predicted)
• PKA: 3.25±0.10(Predicted)
• PSA: 36.68000
• Density: 1.03±0.1 g/cm3(Predicted)
• LogP: 1.82408
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

2-Ethyl-6-methylisonicotinonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Ethyl-6-Methylisonicotinonitrile

There total 4 articles about 2-Ethyl-6-Methylisonicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

ethylmagnesium bromide (925-90-6) + 2-chloro-6-methyl-pyridine-4-carbonitrile (25462-98-0) → 2-ethyl-6-methylpyridine-4-carbonitrile (945463-94-5)

Guidance literature:

With iron(III)-acetylacetonate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 20 ℃; Inert atmosphere;

Reference yield:

2-ethyl-6-methyl-isonicotinamide (1122091-62-6) → 2-ethyl-6-methylpyridine-4-carbonitrile (945463-94-5)

Guidance literature:

With pyridine; trifluoroacetic anhydride; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

2-ethyl-6-methylisonicotinic acid hydrochloride (945463-99-0) → 2-ethyl-6-methylpyridine-4-carbonitrile (945463-94-5)

Guidance literature:

2-ethyl-6-methylisonicotinic acid hydrochloride; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

With ammonia; In 1,4-dioxane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

With pyridine; water; sodium carbonate; trifluoroacetic anhydride; more than 3 stages;

upstream raw materials:

2-ethyl-6-methylisonicotinic acid hydrochloride

2-ethyl-6-methyl-isonicotinamide

ethyl 2-ethyl-6-methylisonicotinate

ethylmagnesium bromide

Refernces

• 1、 -. "CGRP RECEPTOR ANTAGONISTS". Page/Page column 18; 18; 49. . Retrieved 2017/03/08.
• 2、 -. "Novel Pyridine Derivatives". Page/Page column 13. . Retrieved 2009/01/24.