3,5-Diamino-6-chloropicolinic acid

Base Information

• Chemical Name: 3,5-Diamino-6-chloropicolinic acid
• CAS No.: 465513-12-6
• Molecular Formula: C6H6ClN3O2
• Molecular Weight: 187.58
• Hs Code.: 2933399090
• Mol file: 465513-12-6.mol

Synonyms:3,5-Diamino-6-chloropicolinic acid

Chemical Property of 3,5-Diamino-6-chloropicolinic acid

Chemical Property:

• PSA: 102.23000
• LogP: 1.76000

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-Diamino-6-chloropicolinic acid

There total 6 articles about 3,5-Diamino-6-chloropicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3,5-diacetylamino-6-chloropyridine-2-carboxylic acid (353281-78-4) → 3,5-diamino-6-chloropyridine-2-carboxylic acid (465513-12-6)

Guidance literature:

With sodium hydroxide; for 3h; Heating;

DOI:10.1016/S0968-0896(02)00022-6

Reference yield:

2-hydroxy-6-methyl-3,5-dinitropyridine (15889-25-5) → 3,5-diamino-6-chloropyridine-2-carboxylic acid (465513-12-6)

Guidance literature:

Multi-step reaction with 5 steps

1: PCl₅; POCl₃

2: 60 percent / SnCl₂; 12N HCl / 20 - 100 °C

3: 90 percent / 0.5 h / 20 °C

4: 60 percent / MgSO₄; KMnO₄ / H₂O / 1 h

5: 75 percent / 1N NaOH / 3 h / Heating

With hydrogenchloride; sodium hydroxide; potassium permanganate; phosphorus pentachloride; magnesium sulfate; tin(ll) chloride; trichlorophosphate; In water;

DOI:10.1016/S0968-0896(02)00022-6

Reference yield:

2-amino-3,5-dinitro-6-methylpyridine (25864-34-0) → 3,5-diamino-6-chloropyridine-2-carboxylic acid (465513-12-6)

Guidance literature:

Multi-step reaction with 6 steps

1: NaNO₂; H₂SO₄

2: PCl₅; POCl₃

3: 60 percent / SnCl₂; 12N HCl / 20 - 100 °C

4: 90 percent / 0.5 h / 20 °C

5: 60 percent / MgSO₄; KMnO₄ / H₂O / 1 h

6: 75 percent / 1N NaOH / 3 h / Heating

With hydrogenchloride; sodium hydroxide; potassium permanganate; phosphorus pentachloride; sulfuric acid; magnesium sulfate; tin(ll) chloride; sodium nitrite; trichlorophosphate; In water;

DOI:10.1016/S0968-0896(02)00022-6

upstream raw materials:

3,5-diacetylamino-6-chloropyridine-2-carboxylic acid

2-hydroxy-6-methyl-3,5-dinitropyridine

2-amino-3,5-dinitro-6-methylpyridine

3,5-diamino-2-chloro-6-methylpyridine

Refernces