(R)-4-((S)-2-((E)-3-(4-chlorophenyl)acrylaMido)propanaMido)-N1-((S)-1,6-diaMino-1-oxohexan-2-yl)pentanediaMide

Base Information

Chemical Name:(R)-4-((S)-2-((E)-3-(4-chlorophenyl)acrylaMido)propanaMido)-N1-((S)-1,6-diaMino-1-oxohexan-2-yl)pentanediaMide
CAS No.:1340480-93-4
Molecular Formula:C23H33ClN6O5
Molecular Weight:508.99832
Hs Code.:
Mol file:1340480-93-4.mol

Synonyms:(R)-4-((S)-2-((E)-3-(4-chlorophenyl)acrylaMido)propanaMido)-N1-((S)-1,6-diaMino-1-oxohexan-2-yl)pentanediaMide

Suppliers and Price of (R)-4-((S)-2-((E)-3-(4-chlorophenyl)acrylaMido)propanaMido)-N1-((S)-1,6-diaMino-1-oxohexan-2-yl)pentanediaMide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 6 raw suppliers

Chemical Property of (R)-4-((S)-2-((E)-3-(4-chlorophenyl)acrylaMido)propanaMido)-N1-((S)-1,6-diaMino-1-oxohexan-2-yl)pentanediaMide

Chemical Property:

Melting Point:215-217 °C
Boiling Point:965.7±65.0 °C(Predicted)
PKA:12.81±0.46(Predicted)
Density:1.279±0.06 g/cm3(Predicted)

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of (R)-4-((S)-2-((E)-3-(4-chlorophenyl)acrylaMido)propanaMido)-N1-((S)-1,6-diaMino-1-oxohexan-2-yl)pentanediaMide

There total 30 articles about (R)-4-((S)-2-((E)-3-(4-chlorophenyl)acrylaMido)propanaMido)-N1-((S)-1,6-diaMino-1-oxohexan-2-yl)pentanediaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.5%

: C₃₁H₃₉ClN₆O₇

: 1340480-93-4
Nα-[4-chlorocinnamoyl-L-alanyl-D-isoglutaminyl]-L-lysine

Guidance literature:: With boron trifluoride diethyl etherate; trifluoroacetic acid; In ethanol; at 20 ℃; for 2h;

Reference yield: 72.0%

: Nα-[4-chlorocinnamoyl-L-alanyl-D-isoglutaminyl]-Nε-carbobenzyloxy-L-lysine

: 1286246-27-2,1340480-93-4
Nα-[4-chlorocinnamoyl-L-alanyl-D-isoglutaminyl]-L-lysine

Guidance literature:: With boron trifluoride diethyl etherate; trifluoroacetic acid; ethanethiol; at 20 ℃; for 2h;
DOI:10.1016/j.cclet.2011.07.020

Reference yield:

: 131450-55-0
C₁₃H₁₀ClNO₄

: 1286246-27-2,1340480-93-4
Nα-[4-chlorocinnamoyl-L-alanyl-D-isoglutaminyl]-L-lysine

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 29 h / 0 - 20 °C

2: hydrogen bromide; acetic acid / 3 h / 20 °C

3: diisopropyl-carbodiimide / tetrahydrofuran / 25 h / 0 - 20 °C

4: tetrahydrofuran / 29 h / 0 - 20 °C

5: boron trifluoride diethyl etherate; trifluoroacetic acid; ethanethiol / 2 h / 20 °C

With boron trifluoride diethyl etherate; hydrogen bromide; acetic acid; trifluoroacetic acid; ethanethiol; diisopropyl-carbodiimide; In tetrahydrofuran;
DOI:10.1016/j.cclet.2011.07.020