C-(4-P-TOLYL-TETRAHYDRO-PYRAN-4-YL)-METHYLAMINE

Base Information

• Chemical Name: C-(4-P-TOLYL-TETRAHYDRO-PYRAN-4-YL)-METHYLAMINE
• CAS No.: 619296-06-9
• Molecular Formula: C13H19NO
• Molecular Weight: 205.3
• Hs Code.: 2932999099
• Mol file: 619296-06-9.mol

Synonyms:C-(4-P-TOLYL-TETRAHYDRO-PYRAN-4-YL)-METHYLAMINE

Chemical Property of C-(4-P-TOLYL-TETRAHYDRO-PYRAN-4-YL)-METHYLAMINE

Chemical Property:

• PSA: 35.25000
• LogP: 2.70220

Purity/Quality:

98%min ^*data from raw suppliers

C-(4-p-Tolyl-tetrahydro-pyran-4-yl)-methylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of C-(4-P-TOLYL-TETRAHYDRO-PYRAN-4-YL)-METHYLAMINE

There total 2 articles about C-(4-P-TOLYL-TETRAHYDRO-PYRAN-4-YL)-METHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C13H15NO → [4-(4-methylphenyl)tetrahydro-2H-pyran-4-yl]methylamine (619296-06-9)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; benzene; for 12h; Heating;

DOI:10.1134/S1070428016020081

Reference yield:

(4-methylphenyl)acetonitrile (2947-61-7) → [4-(4-methylphenyl)tetrahydro-2H-pyran-4-yl]methylamine (619296-06-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / N,N-dimethyl-formamide / 0.5 h

1.2: 4 h / 70 - 75 °C

2.1: lithium aluminium tetrahydride / diethyl ether; benzene / 12 h / Heating

With lithium aluminium tetrahydride; sodium hydroxide; In diethyl ether; N,N-dimethyl-formamide; benzene;

DOI:10.1134/S1070428016020081

Reference yield:

[4-(4-methylphenyl)tetrahydro-2H-pyran-4-yl]methylamine (619296-06-9) → 3-{[4-(4-methylphenyl)tetrahydro-2H-pyran-4-yl]methyl}-5-(phenoxymethyl)oxazolidine

Guidance literature:

Multi-step reaction with 2 steps

1: water / isopropyl alcohol / 20 h / Heating

2: ethanol; water / 24 h / Heating

With water; In ethanol; water; isopropyl alcohol;

DOI:10.1134/S1070428016020081

upstream raw materials:

(4-methylphenyl)acetonitrile

Refernces