2,2-Dimethyl-chroman-4-ylamine

Base Information

• Chemical Name: 2,2-Dimethyl-chroman-4-ylamine
• CAS No.: 220634-41-3
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.246
• Hs Code.: 2932999099
• European Community (EC) Number: 964-054-5
• DSSTox Substance ID: DTXSID90571719
• Mol file: 220634-41-3.mol

Synonyms:220634-41-3;2,2-Dimethyl-chroman-4-ylamine;2,2-DIMETHYLCHROMAN-4-AMINE;(2,2-DIMETHYL-3,4-DIHYDRO-2H-CHROMEN-4-YL)AMINE;2,2-dimethyl-3,4-dihydrochromen-4-amine;2,2-DIMETHYL-3,4-DIHYDRO-2H-1-BENZOPYRAN-4-AMINE;2,2-dimethyl-4-amino chroman;SCHEMBL1237664;DTXSID90571719;YSTIIIRGSQEQNH-UHFFFAOYSA-N;MFCD08687615;AKOS000302839;AKOS016046345;AB48191;AS-48270;CS-0308028;EN300-105476;F30127;F8888-2672;Z1235966169;(2,2-dimethyl-3,4-dihydro-2H-chromen-4-yl)amine(SALTDATA: HCl)

Chemical Property of 2,2-Dimethyl-chroman-4-ylamine

Chemical Property:

• PSA: 35.25000
• LogP: 2.94780
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 177.115364102
• Heavy Atom Count: 13
• Complexity: 191

Purity/Quality:

98%min ^*data from raw suppliers

(2,2-dimethyl-3,4-dihydro-2H-chromen-4-yl)amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CC(C2=CC=CC=C2O1)N)C

Technology Process of 2,2-Dimethyl-chroman-4-ylamine

There total 5 articles about 2,2-Dimethyl-chroman-4-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-hydroxyimine → 4-amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran (220634-41-3,235423-04-8)

Guidance literature:

With hydrogen; nickel; In methanol; at 25 ℃; under 3750.38 Torr;

DOI:10.1016/j.bmc.2008.04.043

Reference yield:

3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-hydroxyimine (24700-17-2) → 4-amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran (220634-41-3,235423-04-8)

Guidance literature:

3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-hydroxyimine; With acetic acid; zinc; for 4 - 8h; Reflux;

With sodium hydroxide; In water; at 20 ℃; pH=9 - 11;

Reference yield:

2,3-dihydro-2,2-dimethylbenzo[b]pyran-4-one (3780-33-4) → 4-amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran (220634-41-3,235423-04-8)

Guidance literature:

2,3-dihydro-2,2-dimethylbenzo[b]pyran-4-one; With ammonium acetate; sodium cyanoborohydride; In methanol; for 24h;

With hydrogenchloride; In methanol; water; pH=< 1;

With potassium hydroxide; In methanol; water;

upstream raw materials:

4-azido-2,2-dimethyl-3,4-dihydro-2H-chromene

2,3-dihydro-2,2-dimethylbenzo[b]pyran-4-one

3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-hydroxyimine

Downstream raw materials:

C₁₈H₁₉ClN₂O₂

C₁₈H₁₉ClN₂O₂