6-(2-FLUOROPHENYL)IMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBALDEHYDE

Base Information

• Chemical Name: 6-(2-FLUOROPHENYL)IMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBALDEHYDE
• CAS No.: 439095-02-0
• Molecular Formula: C12H7FN2OS
• Molecular Weight: 246.26
• Hs Code.: 2934100090
• Mol file: 439095-02-0.mol

Synonyms:6-(2-FLUOROPHENYL)IMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBALDEHYDE;6-(2-FLUOROPHENYL)IMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBOXALDEHYDE;BUTTPARK 30\02-13

Chemical Property of 6-(2-FLUOROPHENYL)IMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBALDEHYDE

Chemical Property:

• Melting Point: 147-148°C
• PSA: 62.61000
• LogP: 3.01440

Purity/Quality:

97% ^*data from raw suppliers

6-(2-Fluorophenyl)imidazo[2,1-b][1,3]thiazole-5-carboxaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(2-FLUOROPHENYL)IMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBALDEHYDE

There total 2 articles about 6-(2-FLUOROPHENYL)IMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C11H7FN2S (439094-75-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → C12H7FN2OS (439095-02-0)

Guidance literature:

N,N-dimethyl-formamide; With trichlorophosphate; In chloroform; at 0 - 5 ℃;

C₁₁H₇FN₂S; In chloroform; Cooling; Reflux;

DOI:10.1016/j.ejmech.2011.07.001

Reference yield:

2-bromo-2'-fluoroacetophenone (655-15-2) → C12H7FN2OS (439095-02-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetone / Reflux

1.2: Reflux

2.1: trichlorophosphate / chloroform / 0 - 5 °C

2.2: Cooling; Reflux

With trichlorophosphate; In chloroform; acetone; 2.1: Vilsmeier reaction / 2.2: Vilsmeier reaction;

DOI:10.1016/j.ejmech.2011.07.001

Reference yield: 25.0%

C12H7FN2OS (439095-02-0) + ethyl acetoacetate (141-97-9) → diethyl 4-[6-(2-fluorophenyl)imidazo[2,1-b][1,3]thiazol-5-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:

With ammonium hydroxide; In isopropyl alcohol; for 12h; Reflux;

DOI:10.1016/j.ejmech.2019.02.075

upstream raw materials:

C₁₁H₇FN₂S

N,N-dimethyl-formamide

2-bromo-2'-fluoroacetophenone

Downstream raw materials:

NSC 747415

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